Acute myeloid leukaemia: optimal management and recent developments
L Villela, J Bolaños-Meade - Drugs, 2011 - Springer
The current treatment of patients with acute myeloid leukaemia yields poor results, with
expected cure rates in the order of 30–40% depending on the biological characteristics of …
expected cure rates in the order of 30–40% depending on the biological characteristics of …
The response to induction therapy is crucial for the treatment outcomes of elderly patients with acute myeloid leukemia: single-institution experience
T Tasaki, T Yamauchi, Y Matsuda, M Takai… - Anticancer …, 2014 - ar.iiarjournals.org
Background/Aim: The prognosis of acute myeloid leukemia (AML) in elderly patients
remains poor due to their poor general condition and the intrinsic chemotherapy-resistant …
remains poor due to their poor general condition and the intrinsic chemotherapy-resistant …
Biochemical modulation of aracytidine (Ara-C) effects by GTI-2040, a ribonucleotide reductase inhibitor, in K562 human leukemia cells
P Chen, J Aimiuwu, Z Xie, X Wei, S Liu, R Klisovic… - The AAPS journal, 2011 - Springer
GTI-2040 is a potent antisense to the M2 subunit of the ribonucleotide reductase (RNR), an
enzyme involved in the de novo synthesis of nucleoside triphosphates. We hypothesized …
enzyme involved in the de novo synthesis of nucleoside triphosphates. We hypothesized …
Chronic Lymphocytic Leukaemia
CD CD19 - PRESCRIBING FOR ELDERLY PATIENTS - Wiley Online Library
Chronic lymphocytic leukaemia (CLL) is the most common leukaemia in adults and with a
median age at presentation of 70 years. It displays heterogeneity in both biology and clinical …
median age at presentation of 70 years. It displays heterogeneity in both biology and clinical …
Modulation of Pharmacologic Effects of 5-Azacytidine by Ribonucleotide Reductase Antisense GTI-2040
JE Aimiuwu - 2011 - rave.ohiolink.edu
Cancer, like most human diseases is complex and the therapeutic approaches available to
treat this disease have limited efficacy. Therefore, combination studies of two or more …
treat this disease have limited efficacy. Therefore, combination studies of two or more …
17 Haematological disorders
BJ Kuss, S Alhashami - Prescribing for Elderly Patients, 2009 - Wiley Online Library
Haematological diseases or abnormalities are common among the elderly. Anaemia due to
a variety of chronic illnesses or underlying pathology; myelodysplasia and chronic …
a variety of chronic illnesses or underlying pathology; myelodysplasia and chronic …
Pharmacokinetic-pharmacodynamic Studies of 5-azacytidine in Combination with GTI-2040
P Chen - 2008 - rave.ohiolink.edu
Leukemia is the most common blood cancer and is characterized by the increased
expansion of abnormal blood cells. Important insights into the pathogenesis of this disease …
expansion of abnormal blood cells. Important insights into the pathogenesis of this disease …