Vitamin D is one of the oldest hormones. 1 Early in evolution as unicellular organisms
evolved and took advantage of the sun's energy for photosynthesis of sugars, they also …

Vitamin D, the sunshine vitamin, has been important not only for the evolution of a healthy
calcified vertebrate skeleton but it also evolved into a hormone that has a wide diversity of …

Cytochrome P450s (CYPs) represent a large class of heme-containing enzymes that
catalyze the metabolism of multitudes of substrates both endogenous and exogenous. Until …

Although the kidney was initially thought to be the sole organ responsible for the production
of 1, 25 (OH) 2 D via the enzyme CYP27b1, it is now appreciated that the expression of …

Ultraviolet B (UVB), in addition to having carcinogenic activity, is required for the production
of vitamin D3 (D3) in the skin which supplies> 90% of the body's requirement. Vitamin D is …

A low vitamin D status and inadequate calcium intake are important risk factors for various
types of cancer. Ecological studies using solar UV-B exposure as an index of vitamin D3 …

Besides its classical biological effects on calcium and phosphorus homeostasis, calcitriol,
the active vitamin D metabolite, has a broad variety of actions including anticancer effects …

Melanoma represents a significant clinical problem affecting a large segment of the
population with a relatively high incidence and mortality rate. Ultraviolet radiation (UVR) is …

Vitamin D deficiency and low calcium intake are considered risk factors for several cancers.
Vitamin D, synthesized in the skin or ingested through the diet, is transformed through two …

Epidemiologic studies implicate vitamin D status as a factor that influences growth of EGFR
mutant lung cancers. However, laboratory based evidence of the biological effect of vitamin …