Lymphangiogenesis and lymphatic metastasis in breast cancer

S Ran, L Volk, K Hall, MJ Flister - Pathophysiology, 2010 - Elsevier
Lymphatic metastasis is the main prognostic factor for survival of patients with breast cancer
and other epithelial malignancies. Mounting clinical and experimental data suggest that …

Role of angiogenesis in inflammatory bowel disease

IE Koutroubakis, G Tsiolakidou… - Inflammatory bowel …, 2006 - academic.oup.com
Several studies have shown alterations in vascular anatomy and physiology in inflammatory
bowel disease (IBD). These findings, together with the observed upregulation of the …

[HTML][HTML] Macrophages, inflammation, and tumor suppressors: ARF, a new player in the game

PG Través, A Luque, S Hortelano - Mediators of inflammation, 2012 - hindawi.com
The interaction between tumor progression and innate immune system has been well
established in the last years. Indeed, several lines of clinical evidence indicate that immune …

Effect and molecular mechanisms of traditional Chinese medicine on tumor targeting tumor-associated macrophages

J He, P Yin, K Xu - Drug Design, Development and Therapy, 2020 - Taylor & Francis
Traditional Chinese medicine (TCM) has been used as a significant cancer treatment
method for many years in China. It has been demonstrated that TCM could assist in …

Histology of colorectal carcinoma: proven and purported prognostic factors

M Johncilla, RK Yantiss - Surgical pathology clinics, 2020 - surgpath.theclinics.com
Although tumor stage has a profound influence on prognosis, several histologic features are
also important. These parameters predict biological behavior and can be used by clinicians …

Differential Cytokine Responses in Human and Mouse Lymphatic Endothelial Cells to Cytokines in Vitro

GV Chaitanya, SE Franks, W Cromer… - … research and biology, 2010 - liebertpub.com
Background: Inflammatory cytokines dysregulate microvascular function, yet how cytokines
affect lymphatic endothelial cells (LEC) are unclear. Methods and Results: We examined …

Lymphangiogenesis and lymphovascular invasion diminishes prognosis in esophageal cancer

SF Schoppmann, B Jesch, J Zacherl, MF Riegler… - Surgery, 2013 - Elsevier
BACKGROUND: Tumor-associated lymphatic networks are the primary routes for tumor cell
dissemination and metastasis. Behind the background of possible lymphangiogenesis …

Carcinogenesis: the cancer cell–mast cell connection

MA Aller, A Arias, JI Arias, J Arias - Inflammation Research, 2019 - Springer
Background In mammals, inflammation is required for wound repair and tumorigenesis.
However, the events that lead to inflammation, particularly in non-healing wounds and …

MiR-128-3p directly targets VEGFC/VEGFR3 to modulate the proliferation of lymphatic endothelial cells through Ca2+ signaling

J Zhou, Z He, L Guo, J Zeng, P Liang, L Ren… - … International Journal of …, 2018 - Elsevier
Lymphangiogenesis has been regarded as a physiological response to pathologic stimuli.
The abnormal proliferation of lymphatic endothelial cell (LECs) and lymphangiogenesis is …

A heparin conjugate, LHbisD4, inhibits lymphangiogenesis and attenuates lymph node metastasis by blocking VEGF-C signaling pathway

JU Choi, SW Chung, TA Al-Hilal, F Alam, J Park… - Biomaterials, 2017 - Elsevier
Clinical studies have found that the incidence of cancer metastasis through the lymphatic
vessels are 3–5 times higher than that through the blood vessels. These findings suggest …