Reproducible subclassification of ovarian carcinomas is biologically and increasingly
therapeutically important. The traditional morphologic approach that ignores genotype and …

DNA mismatch repair (MMR) deficiency is associated with increased risk of developing
several types of cancer and is the most common cause of hereditary ovarian cancer after …

Loss of mismatch repair (MMR) capacity may represent an important tumor initiating
mechanism in ovarian cancer. We conducted a systematic review to analyze the frequency …

Objective The role of mismatch repair (MMR) deficiency in ovarian cancer (OC)
pathogenesis and its association with other clinicopathologic features, such as microsatellite …

Ovarian cancer ranks fifth in both cancer incidence and mortality among women in the
United States. Defects in the mismatch‐repair (MMR) pathway that arise through genetic …

It was a century ago that Warthin, a pathologist, first described the clinical condition now
known as Lynch syndrome. One hundred years later, our understanding of this syndrome …

Abstract Objective Patients with Lynch Syndrome are at an increased risk for a variety of
malignancies, including ovarian cancer. Ovarian cancers associated with Lynch Syndrome …

Objective Mismatch repair (MMR) deficiency and Bethesda panel microsatellite instability
(MSI) are increasingly analyzed to identify tumors that might benefit from immune checkpoint …

A subset of women with uterine cancer exhibiting defective mismatch repair (MMR) proteins
and microsatellite instability (MSI) may have Lynch syndrome, which also confers a risk for …

Ovarian malignancies occurring in the setting of hereditary nonpolyposis colorectal
carcinoma syndrome typically present in young women, often as the first or “sentinel” cancer …