Folate being an important vitamin of B Complex group in our diet plays an important role not
only in the synthesis of DNA but also in the maintenance of methylation reactions in the …

Background & Aims: Increasing evidence suggests that a low folate intake and impaired
folate metabolism may be implicated in the development of gastrointestinal cancers. We …

Developmental process to gastric cancer by Helicobacter pylori infection consists of three
steps:(1) H. pylori infection;(2) gastric atrophy development; and (3) carcinogenesis. In each …

Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in the metabolism of folate,
whose role in gastric carcinogenesis is controversial. The authors performed a meta …

Background: The gene for 5, 10-methylenetetrahydrofolate reductase (NAD (P) H) or
MTHFR gene encodes protein methylenetetrahydrofolate reductase (MTHFR), an enzyme …

Widely regarded as one of the most prevalent malignancies worldwide, gastric cancer (GC)
is a common clinical condition of the digestive system. Reviewing 14 meta-analyses that …

To clarify the influence of MTHFR C677T and A1298C polymorphisms on gastric cancer
(GC), a meta-analysis of eight case-control studies (1,584/2,785 cases/controls) was carried …

Esophageal cancer has been associated with tobacco and alcohol consumption, gastric
reflux, exposure to nitrosamines from food or other environmental sources, and diets lacking …

Previous studies have shown inconsistent associations of folate intake and polymorphisms
of the methylenetetrahydrofolate reductase (MTHFR) gene with gastric cancer risk. Our …

Purpose Methylenetetrahydrofolate reductase (MTHFR) is the main regulatory enzyme for
homocysteine metabolism. In the present study, we evaluated whether the MTHFR 677C> T …