Although pyroptosis is critical for macrophages against pathogen infection, its role and
mechanism in cancer cells remains unclear. PD-L1 has been detected in the nucleus, with …

NKT cells represent a distinct lineage of T cells that coexpress a conserved αβ T cell receptor
(TCR) and natural killer (NK) receptors. Although the TCR of NKT cells is characteristically …

Early-phase trials targeting the T-cell inhibitory molecule programmed cell death ligand 1 (PD-L1)
have shown clinical efficacy in cancer. This study was undertaken to determine …

Three types of fermions play a fundamental role in our understanding of nature: Dirac,
Majorana and Weyl. Whereas Dirac fermions have been known for decades, the latter two have …

Extracellular interaction between programmed death ligand-1 (PD-L1) and programmed cell
death protein-1 (PD-1) leads to tumour-associated immune escape. Here we show that the …

Context Prediction of high probability of survival from standard cancer treatments is
fundamental for individualized cancer treatment strategies. Objective To develop a predictor of …

As a test of the effectiveness of various methods for searching the conformational space of
highly flexible molecules, we conducted a series of conformational searches on …

The rate of global-mean sea-level rise since 1900 has varied over time, but the contributing
factors are still poorly understood 1 . Previous assessments found that the summed …

Proinflammatory cytokines produced in the tumor microenvironment facilitate tumor
development and metastatic progression. In particular, TNF-α promotes cancer invasion and …

Pro-inflammatory cytokines produced in the tumor microenvironment lead to eradication of
anti-tumor immunity and enhanced tumor cell survival. In the current study, we identified …