Pancreatic cancer remains a highly recalcitrant disease despite the development of
systemic chemotherapies. New treatment options are thus urgently required. Dense stromal …

This paper summarizes the evolution of Japanese DEMO design studies in a retrospective
manner by highlighting efforts to resolve critical design issues on DEMO. Japan is currently …

Purpose The aim of this study was to assess the efficacy of combined resection and
reconstruction (CRR) of the hepatic artery (HA) in surgery for hilar cholangiocarcinoma (HC). …

Background Little is known about the immunological effect of neoadjuvant chemoradiotherapy
(NACRT) in the tumor microenvironment of pancreatic ductal adenocarcinoma. The …

The Joint Special Design Team for Fusion DEMO was organized in 2015 to enhance Japan’s
DEMO design activity and coordinate relevant research and development (R&D) toward …

Background Although distant metastasis from pancreatic ductal adenocarcinoma (PDAC)
has a dismal prognosis, some single center studies reported that lung metastasis has a …

The requirements for Japanese DEMO are to demonstrate (1) steady and stable electrical
power generation, (2) plant availability on a level relevant for commercialization, and (3) self-…

Background The high operative mortality rate after hepatopancreatoduodenectomy (HPD) is
still a major issue. The present study explored why operative mortality differs significantly …

Methionine addiction is a fundamental and general hallmark of cancer. Gene expression
analysis showed that methionine restriction (MR) of methionine-addicted cancer cells increases …

Background: Although surgery is the mainstay of curative-intent treatment for extrahepatic
biliary tract cancer (EBTC), recurrence following surgery can be high and prognosis poor. The …