User profiles for YUJI TAKAOKA

Yuji Takaoka

Schrodinger KK
Verified email at kyoto-u.jp
Cited by 1407

Hydrogen bonding of water to phosphatidylcholine in the membrane as studied by a molecular dynamics simulation: location, geometry, and lipid− lipid bridging via …

M Pasenkiewicz-Gierula, Y Takaoka… - The Journal of …, 1997 - ACS Publications
Hydrogen (H-) bonding between water and phosphatidylcholine was studied using a molecular
dynamics simulation of a hydrated phosphatidylcholine bilayer membrane in the liquid …

[HTML][HTML] Charge pairing of headgroups in phosphatidylcholine membranes: a molecular dynamics simulation study

M Pasenkiewicz-Gierula, Y Takaoka, H Miyagawa… - Biophysical journal, 1999 - cell.com
Molecular dynamics simulation of the hydrated dimyristoylphosphatidylcholine (DMPC) bilayer
membrane in the liquid-crystalline phase was carried out for 5ns to study the interaction …

[PDF][PDF] Effects of phospholipid unsaturation on the membrane/water interface: a molecular simulation study

K Murzyn, T Róg, G Jezierski, Y Takaoka… - Biophysical …, 2001 - cell.com
Molecular dynamics (MD) simulations of fully hydrated bilayers in the liquid-crystalline state
made of 1-palmitoyl-2-oleoyl-phosphatidylcholine (POPC) or 1-palmitoyl-2-elaidoyl-…

Liquid–vapor interface of water–methanol mixture. I. Computer simulation

M Matsumoto, Y Takaoka, Y Kataoka - The Journal of chemical physics, 1993 - pubs.aip.org
Results of molecular dynamics computer simulation are presented for liquid–vapor interface
of water–methanol mixture of various compositions at room temperature. The composition …

Development of a method for evaluating drug-likeness and ease of synthesis using a data set in which compounds are assigned scores based on chemists' intuition

Y Takaoka, Y Endo, S Yamanobe… - Journal of chemical …, 2003 - ACS Publications
The concept of drug-likeness, an important characteristic for any compound in a screening
library, is nevertheless difficult to pin down. Based on our belief that this concept is implicit …

Mitochondrial pyruvate carrier 1 expression controls cancer epithelial‐mesenchymal transition and radioresistance

Y Takaoka, M Konno, J Koseki, H Colvin… - Cancer …, 2019 - Wiley Online Library
Mitochondrial pyruvate carrier (MPC) is known to cause different expressions in normal and
cancer cells. We observed a change in phenotype with the suppression of MPC expression. …

[HTML][HTML] Forced Expression of miR-143 Represses ERK5/c-Myc and p68/p72 Signaling in Concert with miR-145 in Gut Tumors of ApcMin Mice

Y Takaoka, Y Shimizu, H Hasegawa, Y Ouchi, S Qiao… - 2012 - journals.plos.org
Recently, miR-143 and miR-145 have been shown to belong to a subset of microRNAs
whose expression is controlled by a complex of a tumor suppressor p53 and DEAD-box RNA …

[HTML][HTML] Effects of phospholipid unsaturation on the bilayer nonpolar region: a molecular simulation study

T Róg, K Murzyn, R Gurbiel, Y Takaoka, A Kusumi… - Journal of lipid …, 2004 - ASBMB
Molecular dynamics simulations of two monounsaturated phosphatidylcholine (PC) bilayers
made of 1-palmitoyl-2-oleoyl-PC (POPC; cis-unsaturated) and 1-palmitoyl-2-elaidoyl-PC (…

Synthesis and structure–activity relationships of potent 3-or 4-substituted-2-cyanopyrrolidine dipeptidyl peptidase IV inhibitors

…, E Munetomo, K Kitano, H Saito, Y Takaoka… - Bioorganic & medicinal …, 2004 - Elsevier
Dipeptidyl peptidase IV (DPP-IV) inhibitors have attracted attention as potential drugs for
use in the treatment of type 2 diabetes because they prevent degradation of glucagon-like …

[HTML][HTML] Forced expression of miR-143 and-145 in cardiomyocytes induces cardiomyopathy with a reductive redox shift

…, Y Fujihara, M Ichihara, K Adachi, Y Takaoka… - Cellular & Molecular …, 2020 - Springer
Background Animal model studies show that reductive stress is involved in cardiomyopathy
and myopathy, but the exact physiological relevance remains unknown. In addition, the …