Potential therapeutic agents for COVID-19 based on the analysis of protease and RNA polymerase docking

YC Chang, YA Tung, KH Lee, TF Chen, YC Hsiao… - 2020 - preprints.org
The outbreak of novel coronavirus (COVID-19) infections in 2019 is in dire need of finding
potential therapeutic agents. In this study, we used molecular docking to repurpose HIV …

Mapping the signaling network of BIN2 kinase using TurboID-mediated biotin labeling and phosphoproteomics

…, YW Kim, YW Ko, Z Zhang, JY Zhu, YC Hsiao… - The Plant …, 2023 - academic.oup.com
Elucidating enzyme–substrate relationships in posttranslational modification (PTM) networks
is crucial for understanding signal transduction pathways but is technically difficult because …

DockCoV2: a drug database against SARS-CoV-2

…, YC Chang, Y Hsiao, KH Lee, YC Hsiao… - Nucleic Acids …, 2021 - academic.oup.com
The current state of the COVID-19 pandemic is a global health crisis. To fight the novel
coronavirus, one of the best-known ways is to block enzymes essential for virus replication. …

A t RH 57, a DEAD‐box RNA helicase, is involved in feedback inhibition of glucose‐mediated abscisic acid accumulation during seedling development and additively …

YF Hsu, YC Chen, YC Hsiao, BJ Wang, SY Lin… - The Plant …, 2014 - Wiley Online Library
The A rabidopsis thaliana T ‐ DNA insertion mutant rh57‐1 exhibited hypersensitivity to
glucose ( G lc) and abscisic acid ( ABA ). The other two rh57 mutants also showed G lc …

Stromal cell-derived factor-1 enhances motility and integrin up-regulation through CXCR4, ERK and NF-κB-dependent pathway in human lung cancer cells

YC Huang, YC Hsiao, YJ Chen, YY Wei, TH Lai… - Biochemical …, 2007 - Elsevier
The chemokine stromal-derived factor-1α (SDF-1α) and its receptor, CXCR4, play a crucial
role in adhesion and migration of human cancer cells. Integrins are the major adhesive …

TGF-β1 increases motility and αvβ3 integrin up-regulation via PI3K, Akt and NF-κB-dependent pathway in human chondrosarcoma cells

YY Yeh, CC Chiao, WY Kuo, YC Hsiao, YJ Chen… - Biochemical …, 2008 - Elsevier
Transforming growth factor-β1 (TGF-β1) plays an essential role in tumor progression and
metastasis. Integrins are the major adhesive molecules in mammalian cells. Here we found that …

Vastly improved solar-light induced water splitting catalyzed by few-layer MoS2 on Au nanoparticles utilizing localized surface plasmon resonance

YS Huang, YC Hsiao, SH Tzeng, YH Wu, TP Perng… - Nano Energy, 2020 - Elsevier
Photocatalytic water splitting with few-layer MoS 2 as photocatalysts has been an efficient
hydrogen production method in recent years. Previous studies have shown that active edge …

[HTML][HTML] Dietary high-fat lard intake induces thyroid dysfunction and abnormal morphology in rats

S Shao, Y Zhao, Y Song, C Xu, J Yang… - Acta Pharmacologica …, 2014 - nature.com
Aim: Excess dietary fat intake can induce lipotoxicity in non-adipose tissues. The aim of this
study was to observe the effects of dietary high-fat lard intake on thyroid in rats. Methods: …

[HTML][HTML] Cigarette smoke-induced LKB1/AMPK pathway deficiency reduces EGFR TKI sensitivity in NSCLC

…, BW Wang, MC Yu, TC Hsia, YL Wei, YC Hsiao… - Oncogene, 2021 - nature.com
Smoker patients with non-small cell lung cancer (NSCLC) have poorer prognosis and
survival than those without smoking history. However, the mechanisms underlying the low …

Emodin induces apoptosis in human prostate cancer cell LNCaP

CX Yu, XQ Zhang, LD Kang, PJ Zhang… - Asian journal of …, 2008 - Wiley Online Library
Aim: To elucidate effects and mechanisms of emodin in prostate cancer cells. Methods: Viability
of emodin‐treated LNCaP cells and PC‐3 cells was measured by MTT assay. Following …