In this study, we demonstrated that IL-6 was a possible autocrine growth factor for rat mesangial
cells (MC). rIL-6 induced in vitro growth of rat MC at a concentration of 2 to 200 ng/ml …

BACKGROUND: Complex, highly variable, anatomic relationships in the portal hilum complicate
the surgical management at hilar cholangiocarcinoma. Preoperative three-dimensional (…

Circadian disruption accelerates cancer progression, whereas circadian reinforcement could
halt it. Mice with P03 pancreatic adenocarcinoma (n = 77) were synchronized and fed ad …

We evaluated the diagnostic and prognostic efficacy of human epididymis protein 4 (HE4)
for lung cancer patients by using our novel enzyme-linked immunosorbent assay (ELISA) …

Hepatectomy with vascular reconstruction for biliary malignancy remains controversial. This
study aimed to clarify the indications for surgery. Patients with advanced hilar bile duct …

Gemcitabine has been one of the most commonly used agents for pancreatic adenocarcinoma
chemotherapy, but the determinants of the sensitivity of and resistance to this agent are …

Massive arterial hemorrhage is, although unusual, a life-threatening complication of major
pancreatobiliary surgery. Records of 351 patients who underwent major surgery for malignant …

Quantification of glomerular TGF-β1 mRNA in patients with diabetes mellitus. Transforming
growth factor-β1 (TGF-β1) is a primary determinant of the mesangial expansion observed in …

Mesangial proliferative glomerulonephritis (mesPGN) is histologically characterized by
proliferation of mesangial cells (MC), suggesting the involvement of a growth factor for MC in the …

We determined the relative value of the metastatic colorectal cancer doubling time as a
predictor of recurrence and survival after hepatectomy in comparison with other established …