IDH2 stabilizes HIF‐1α‐induced metabolic reprogramming and promotes chemoresistance in urothelial cancer

K Shigeta, M Hasegawa, T Hishiki, Y Naito… - The EMBO …, 2023 - embopress.org
Drug resistance contributes to poor therapeutic response in urothelial carcinoma (UC).
Metabolomic analysis suggested metabolic reprogramming in gemcitabine‐resistant urothelial …

[HTML][HTML] 2-Nitroimidazoles induce mitochondrial stress and ferroptosis in glioma stem cells residing in a hypoxic niche

N Koike, R Kota, Y Naito, N Hayakawa… - Communications …, 2020 - nature.com
Under hypoxic conditions, nitroimidazoles can replace oxygen as electron acceptors, thereby
enhancing the effects of radiation on malignant cells. These compounds also accumulate …

[HTML][HTML] On-tissue polysulfide visualization by surface-enhanced Raman spectroscopy benefits patients with ovarian cancer to predict post-operative chemosensitivity

…, M Shiota, D Koike, M Naya, N Hayakawa, Y Naito… - Redox Biology, 2021 - Elsevier
Chemosensitivity to cisplatin derivatives varies among individual patients with intractable
malignancies including ovarian cancer, while how to unlock the resistance remain unknown. …

Predictive value of CD73 expression for the efficacy of immune checkpoint inhibitors in NSCLC

…, A Kawahara, T Kinoshita, N Matsuo, Y Naito… - Thoracic …, 2020 - Wiley Online Library
Background CD73 induces the dephosphorylation of adenosine monophosphate converting
it to adenosine, enabling malignancies to escape from immune surveillance. Although …

The hypotaurine-taurine pathway as an antioxidative mechanism in patients with acute liver failure

T Mizota, T Hishiki, M Shinoda, Y Naito… - Journal of Clinical …, 2021 - jstage.jst.go.jp
The liver has been thought to protect against oxidative stress through mechanisms involving
reduced glutathione (GSH) that consumes high-energy phosphor-nucleotides on its …

[HTML][HTML] Comprehensive geriatric assessment as a useful tool in predicting adverse events in elderly patients with diffuse large B-cell lymphoma

…, R Sakai, I Choi, J Tsukada, H Sasaki, Y Naito… - Scientific Reports, 2022 - nature.com
We conducted a multicenter prospective study on whether a comprehensive geriatric
assessment (CGA) can predict the adverse events (AEs) of chemotherapy in elderly patients with …

Role of regulatory T cells in airway inflammation in asthma

…, T Kinoshita, K Matsunaga, Y Naito… - The Kurume medical …, 2017 - jstage.jst.go.jp
Summary: Asthma is an allergic disease characterized by chronic airway inflammation,
airway hyperresponsiveness (AHR), reversibility and remodeling. Inhaled corticosteroids (ICS) …

Retrospective analysis of treatment outcomes and geriatric assessment in elderly malignant lymphoma patients

Y Naito, H Sasaki, Y Takamatsu, F Kiyomi… - Journal of Clinical and …, 2016 - jstage.jst.go.jp
In recent years, the Comprehensive Geriatric Assessment (CGA), which is used in
gerontology to assess functioning in elderly individuals, has been said to be useful in geriatric …

Prognostic value of serum tumor markers in patients with stage III NSCLC treated with chemoradiotherapy

T Tokito, K Azuma, K Yamada, Y Naito, N Matsuo… - in vivo, 2019 - iv.iiarjournals.org
Background/Aim: Serum tumor markers such as carcinoembryonic antigen and cytokeratin
subunit 19 fragment are generally monitored in non-small cell lung cancer (NSCLC) patients …

Biological and Immunological Properties of Encapsulated Strains of Staphylococcus aureus from Human Sources

K Yoshida, MR Smith, Y Naito - Infection and Immunity, 1970 - Am Soc Microbiol
Of 875 strains of Staphylococcus aureus isolated from human source clinical specimens, 37
(4.2%) were encapsulated strains. These were all negative for clumping factor and could not …