Frequent inactivation of A20 in B-cell lymphomas
…, Y Asakura, S Muto, A Tamura, M Iio, Y Akatsuka… - Nature, 2009 - nature.com
A20 is a negative regulator of the NF-κB pathway and was initially identified as being rapidly
induced after tumour-necrosis factor-α stimulation 1 . It has a pivotal role in regulation of the …
induced after tumour-necrosis factor-α stimulation 1 . It has a pivotal role in regulation of the …
Aberrant PD-L1 expression through 3′-UTR disruption in multiple cancers
…, S Takahashi, T Shibata, H Kawamoto, Y Akatsuka… - Nature, 2016 - nature.com
Successful treatment of many patients with advanced cancer using antibodies against
programmed cell death 1 (PD-1; also known as PDCD1) and its ligand (PD-L1; also known as …
programmed cell death 1 (PD-1; also known as PDCD1) and its ligand (PD-L1; also known as …
Therapy of relapsed leukemia after allogeneic hematopoietic cell transplantation with T cells specific for minor histocompatibility antigens
EH Warren, N Fujii, Y Akatsuka… - Blood, The Journal …, 2010 - ashpublications.org
The adoptive transfer of donor T cells that recognize recipient minor histocompatibility
antigens (mHAgs) is a potential strategy for preventing or treating leukemic relapse after …
antigens (mHAgs) is a potential strategy for preventing or treating leukemic relapse after …
[HTML][HTML] Frequent structural variations involving programmed death ligands in Epstein-Barr virus-associated lymphomas
…, Y Ota, K Izutsu, A Demachi-Okamura, Y Akatsuka… - Leukemia, 2019 - nature.com
Viral infection induces potent cellular immunity and activated intracellular signaling, which
may dictate the driver events involved in immune escape and clonal selection of virus-…
may dictate the driver events involved in immune escape and clonal selection of virus-…
The immunogenicity of a new human minor histocompatibility antigen results from differential antigen processing
…, EH Warren, JA Caldwell, Y Akatsuka… - The Journal of …, 2001 - rupress.org
Minor histocompatibility antigens (mHAgs) present a significant impediment to organ and
bone marrow transplantation between HLA-identical donor and recipient pairs. Here we report …
bone marrow transplantation between HLA-identical donor and recipient pairs. Here we report …
Safety and persistence of WT1-specific T-cell receptor gene− transduced lymphocytes in patients with AML and MDS
…, H Fujiwara, T Nishida, Y Akatsuka… - Blood, The Journal …, 2017 - ashpublications.org
Wilms’ tumor 1 (WT1) is constantly expressed in leukemic cells of acute leukemia and
myelodysplastic syndrome (MDS). A T-cell receptor (TCR) that specifically reacts with WT1 peptide …
myelodysplastic syndrome (MDS). A T-cell receptor (TCR) that specifically reacts with WT1 peptide …
The CC chemokine receptor 4 as a novel specific molecular target for immunotherapy in adult T-Cell leukemia/lymphoma
T Ishida, S Iida, Y Akatsuka, T Ishii, M Miyazaki… - Clinical cancer …, 2004 - AACR
Adult T-cell leukemia/lymphoma (ATLL) is a peripheral T-cell neoplasm with dismal prognosis,
and no optimal therapy has been developed. We tested the defucosylated chimeric anti-…
and no optimal therapy has been developed. We tested the defucosylated chimeric anti-…
Restoration of CD28 Expression in CD28− CD8+ Memory Effector T Cells Reconstitutes Antigen-induced IL-2 Production
MS Topp, SR Riddell, Y Akatsuka, MC Jensen… - The Journal of …, 2003 - rupress.org
The control of many persistent viral infections by Ag-specific cytolytic CD8 + T cells requires
a concurrent virus-specific CD4 + Th cell response. This reflects in part a requirement of …
a concurrent virus-specific CD4 + Th cell response. This reflects in part a requirement of …
[HTML][HTML] Effects of HLA allele and killer immunoglobulin-like receptor ligand matching on clinical outcome in leukemia patients undergoing transplantation with T-cell …
…, H Saji, K Yamamoto, E Maruya, Y Akatsuka… - Biology of Blood and …, 2007 - Elsevier
The responsible human leukocyte antigen (HLA) locus and the role of killer immunoglobulin-like
receptor (KIR) ligand matching on transplantation outcome were simultaneously …
receptor (KIR) ligand matching on transplantation outcome were simultaneously …
Identification of a polymorphic gene, BCL2A1, encoding two novel hematopoietic lineage-specific minor histocompatibility antigens
Y Akatsuka, T Nishida, E Kondo, M Miyazaki… - The Journal of …, 2003 - rupress.org
We report the identification of two novel minor histocompatibility antigens (mHAgs), encoded
by two separate single nucleotide polymorphisms on a single gene, BCL2A1, and restricted …
by two separate single nucleotide polymorphisms on a single gene, BCL2A1, and restricted …