Antiviral and antitumor activity of licorice root extracts

…, T Kanamoto, S Terakubo, H Nakashima, Y Uesawa… - in vivo, 2016 - iv.iiarjournals.org
Background: In the search for anti-viral and antitumor substances from natural resources,
antiviral and antitumor activities of licorice root extract and purified ingredients were …

[HTML][HTML] Analysis of factors associated with hiccups based on the Japanese Adverse Drug Event Report database

R Hosoya, Y Uesawa, R Ishii-Nozawa, H Kagaya - PLoS One, 2017 - journals.plos.org
Hiccups are occasionally experienced by most individuals. Although hiccups are not life-threatening,
they may lead to a decline in quality of life. Previous studies showed that hiccups …

Comprehensive study on potent and selective carbonic anhydrase inhibitors: Synthesis, bioactivities and molecular modelling studies of 4-(3-(2-arylidenehydrazine-1 …

C Yamali, H Sakagami, Y Uesawa, K Kurosaki… - European journal of …, 2021 - Elsevier
In this research, rational design, synthesis, carbonic anhydrases (CAs) inhibitory effects,
and cytotoxicities of the 4-(3-(2-arylidenehydrazine-1-carbonyl)-5-(thiophen-2-yl)-1H-pyrazole-1-…

Analyses of respiratory depression associated with opioids in cancer patients based on the Japanese adverse drug event report database

…, M Uchida, S Suzuki, Y Suga, Y Uesawa… - Biological and …, 2019 - jstage.jst.go.jp
Opioid-induced respiratory depression is a potentially life-threatening adverse drug event.
The purpose of this study was to evaluate the incidence of respiratory depression using the …

[HTML][HTML] Optimization of a deep-learning method based on the classification of images generated by parameterized deep snap a novel molecular-image-input …

Y Matsuzaka, Y Uesawa - Frontiers in bioengineering and …, 2019 - frontiersin.org
Numerous chemical compounds are distributed around the world and may affect the
homeostasis of the endocrine system by disrupting the normal functions of hormone receptors. …

[HTML][HTML] Quantitative structure–activity relationship analysis using deep learning based on a novel molecular image input technique

Y Uesawa - Bioorganic & medicinal chemistry letters, 2018 - Elsevier
Quantitative structure–activity relationship (QSAR) analysis uses structural, quantum
chemical, and physicochemical features calculated from molecular geometry as explanatory …

[HTML][HTML] A toxicity prediction tool for potential agonist/antagonist activities in molecular initiating events based on chemical structures

K Kurosaki, R Wu, Y Uesawa - International Journal of Molecular …, 2020 - mdpi.com
Because the health effects of many compounds are unknown, regulatory toxicology must
often rely on the development of quantitative structure–activity relationship (QSAR) models to …

[HTML][HTML] Comprehensive study of the risk factors for medication-related osteonecrosis of the jaw based on the Japanese Adverse Drug Event Report Database

S Toriumi, A Kobayashi, Y Uesawa - Pharmaceuticals, 2020 - mdpi.com
Medication-related osteonecrosis of the jaw (MRONJ) is associated with many drugs,
including bisphosphonates (BPs). BPs are associated with atypical femoral fractures and …

[HTML][HTML] Evaluation of antibiotic-induced taste and smell disorders using the FDA adverse event reporting system database

Y Kan, J Nagai, Y Uesawa - Scientific reports, 2021 - nature.com
Adverse effects can occur owing to anorexia, which can reduce treatment compliance and
worsen the patients overall condition. One such side effect, namely drug-induced taste and …

[HTML][HTML] Predicting blood-to-plasma concentration ratios of drugs from chemical structures and volumes of distribution in humans

H Mamada, K Iwamoto, Y Nomura, Y Uesawa - Molecular Diversity, 2021 - Springer
Despite their importance in determining the dosing regimen of drugs in the clinic, only a few
studies have investigated methods for predicting blood-to-plasma concentration ratios (Rb). …