The biology of cancer stem cells

NA Lobo, Y Shimono, D Qian… - Annu. Rev. Cell Dev …, 2007 - annualreviews.org
Cancers originally develop from normal cells that gain the ability to proliferate aberrantly
and eventually turn malignant. These cancerous cells then grow clonally into tumors and …

[HTML][HTML] Downregulation of miRNA-200c links breast cancer stem cells with normal stem cells

Y Shimono, M Zabala, RW Cho, N Lobo, P Dalerba… - cell, 2009 - cell.com
Human breast tumors contain a breast cancer stem cell (BCSC) population with properties
reminiscent of normal stem cells. We found 37 microRNAs that were differentially expressed …

[HTML][HTML] Comparison of 2D-and 3D-culture models as drug-testing platforms in breast cancer

Y Imamura, T Mukohara, Y Shimono… - Oncology …, 2015 - spandidos-publications.com
It is becoming recognized that screening of oncology drugs on a platform using two-dimensionally
(2D)-cultured cell lines is unable to precisely select clinically active drugs; therefore …

Single-cell dissection of transcriptional heterogeneity in human colon tumors

…, AA Shelton, B Visser, S Hisamori, Y Shimono… - Nature …, 2011 - nature.com
Cancer is often viewed as a caricature of normal developmental processes, but the extent to
which its cellular heterogeneity truly recapitulates multilineage differentiation processes of …

Cancer stem cells from human breast tumors are involved in spontaneous metastases in orthotopic mouse models

…, MH Bachmann, Y Shimono… - Proceedings of the …, 2010 - National Acad Sciences
To examine the role of breast cancer stem cells (BCSCs) in metastasis, we generated
human-in-mouse breast cancer orthotopic models using patient tumor specimens, labeled with …

Characterization of intracellular signals via tyrosine 1062 in RET activated by glial cell line-derived neurotrophic factor

…, M Ichihara, T Iwashita, H Murakami, Y Shimono… - Oncogene, 2000 - nature.com
Glial cell line derived neurotrophic factor (GDNF) signals through a multicomponent receptor
complex consisting of RET receptor tyrosine kinase and a member of GDNF family receptor …

miR-142 regulates the tumorigenicity of human breast cancer stem cells through the canonical WNT signaling pathway

…, G Somlo, K Lao, PO Brown, MF Clarke, Y Shimono - Elife, 2014 - elifesciences.org
10.7554/eLife.01977.001 MicroRNAs (miRNAs) are important regulators of stem and
progenitor cell functions. We previously reported that miR-142 and miR-150 are upregulated in …

Adipose-derived stem cells enhance human breast cancer growth and cancer stem cell-like properties through adipsin

H Goto, Y Shimono, Y Funakoshi, Y Imamura… - Oncogene, 2019 - nature.com
Tumor microenvironment plays a key role for tumor development and progression. Although
adipose tissue is a predominant component of stroma in mammary tissues and secretes …

[HTML][HTML] MicroRNA regulation of human breast cancer stem cells

Y Shimono, J Mukohyama, S Nakamura… - Journal of clinical …, 2015 - mdpi.com
MicroRNAs (miRNAs) are involved in virtually all biological processes, including stem cell
maintenance, differentiation, and development. The dysregulation of miRNAs is associated …

miR-137 regulates the tumorigenicity of colon cancer stem cells through the inhibition of DCLK1

…, S Hisamori, N Oshima, F Sato, Y Shimono… - Molecular Cancer …, 2016 - AACR
miRNAs have important roles in regulating cancer stem cell (CSC) properties and are
considered to be potential therapeutic targets. However, few studies have focused on miRNAs …