Allele and genotype frequencies of CYP2B6 and CYP3A5 in the Japanese population

M Hiratsuka, Y Takekuma, N Endo, K Narahara… - European journal of …, 2002 - Springer
Heading Abstract Objective. The goal of this study was to determine the frequencies of allelic
variants of CYP2B6 and CYP3A5 in the Japanese population. Methods. Genotyping of …

The use of an in vitro dissolution and absorption system to evaluate oral absorption of two weak bases in pH-independent controlled-release formulations

M Sugawara, S Kadomura, X He, Y Takekuma… - European journal of …, 2005 - Elsevier
The aim of this study was to compare the oral absorption of two weak bases including their
pH-independent controlled-release preparations using an in vitro evaluation system. This …

[HTML][HTML] Onset timing and duration of augmented renal clearance in a mixed intensive care unit

…, M Hayakawa, S Imai, M Sugawara, Y Takekuma - Journal of intensive …, 2023 - Springer
Background Augmented renal clearance (ARC) is associated with lower blood plasma
concentrations of renally excreted drugs; however, its time course is unknown. The current study …

Genotyping of the N-acetyltransferase2 polymorphism in the prediction of adverse drug reactions to isoniazid in Japanese patients

M Hiratsuka, Y Kishikawa, Y Takekuma… - Drug metabolism and …, 2002 - Elsevier
To investigate the association between NAT2 genotypes and the incidence of isoniazid (INH)-induced
adverse reactions, in the hope of identifying a pharmacogenetic approach that …

Ribavirin uptake by cultured human choriocarcinoma (BeWo) cells and Xenopus laevis oocytes expressing recombinant plasma membrane human nucleoside …

T Yamamoto, K Kuniki, Y Takekuma, T Hirano… - European journal of …, 2007 - Elsevier
We investigated the mechanism of the transport of ribavirin (1-β-d-ribofuranosyl-1,2,4-trizole-3-carboxamide)
into placental epithelial cells using human choriocarcinoma (BeWo) cells …

[HTML][HTML] Validation of the usefulness of artificial neural networks for risk prediction of adverse drug reactions used for individual patients in clinical practice

S Imai, Y Takekuma, H Kashiwagi, T Miyai… - PLoS …, 2020 - journals.plos.org
Artificial neural networks are the main tools for data mining and were inspired by the human
brain and nervous system. Studies have demonstrated their usefulness in medicine. …

[HTML][HTML] Impact of systemic dexamethasone dosage on docetaxel-induced oral mucositis in patients with breast cancer

Y Saito, Y Takekuma, T Takeshita, T Oshino… - Scientific Reports, 2023 - nature.com
Oral mucositis (OM) is a common adverse effect of docetaxel-containing treatment. This study
aimed to assess whether dexamethasone (DEX) dose-dependently attenuates docetaxel-…

Benzodiazepine concentrations in the breast milk and plasma of nursing mothers: estimation of relative infant dose

…, M Soma, K Noshiro, Y Takekuma… - Breastfeeding …, 2021 - liebertpub.com
Objective: Benzodiazepines are common therapies for mental illness and insomnia, and are
used during pregnancy and lactation. Although benzodiazepines have been shown to be …

[HTML][HTML] Impact of systemic dexamethasone administration on oral mucositis induced by anthracycline-containing regimens in breast cancer treatment

Y Saito, Y Takekuma, T Takeshita, T Oshino… - Scientific reports, 2022 - nature.com
Oral mucositis (OM) is one of the most common complications associated with chemotherapy.
Here, we evaluated whether systemic dexamethasone (DEX) dosage in prophylactic …

Enhancement of lymphatic transport of lutein by oral administration of a solid dispersion and a self-microemulsifying drug delivery system

…, S Nashimoto, S Yokoyama, Y Takekuma… - European Journal of …, 2018 - Elsevier
Lutein is located in the macula lutea in the human eye. Since humans cannot synthesize lutein
de novo, it must be digested as food. Some studies including our previous study showed …