Increased autophagy in transgenic mice with a G93A mutant SOD1 gene

N Morimoto, M Nagai, Y Ohta, K Miyazaki, T Kurata… - Brain research, 2007 - Elsevier
Autophagy, like the ubiquitin–proteasome system, is considered to play an important role in
preventing the accumulation of abnormal proteins. Rat microtubule-associated protein 1 light …

Tridermal tumorigenesis of induced pluripotent stem cells transplanted in ischemic brain

H Kawai, T Yamashita, Y Ohta… - Journal of Cerebral …, 2010 - journals.sagepub.com
Stroke is a major neurologic disorder. Induced pluripotent stem (iPS) cells can be produced
from basically any part of patients, with high reproduction ability and pluripotency to …

Lectin-reactive profiles of alpha-fetoprotein characterizing hepatocellular carcinoma and related conditions

K Taketa, C Sekiya, M Namiki, K Akamatsu, Y Ohta… - Gastroenterology, 1990 - Elsevier
Serum alpha-fetoprotein from 146 patients with hepatocellular carcinoma, other malignancies,
and benign liver diseases, was fractionated by lectin-affinity electrophoresis coupled with …

Disruption of neurovascular unit prior to motor neuron degeneration in amyotrophic lateral sclerosis

K Miyazaki, Y Ohta, M Nagai… - Journal of …, 2011 - Wiley Online Library
Recent reports suggest that functional or structural defect of vascular components are
implicated in amyotrophic lateral sclerosis (ALS) pathology. In the present study, we examined a …

Differences between Australian and Japanese students in decisional self-esteem, decisional stress, and coping styles

MHB Radford, L Mann, Y Ohta… - Journal of cross-cultural …, 1993 - journals.sagepub.com
In this article, the effect of culture on decisional self-esteem, decisional stress, and self-reported
decision coping styles is examined. Results of a questionnaire study of 743 Japanese …

Expression of Keap1–Nrf2 system and antioxidative proteins in mouse brain after transient middle cerebral artery occlusion

N Tanaka, Y Ikeda, Y Ohta, K Deguchi, F Tian, J Shang… - Brain research, 2011 - Elsevier
Reactive oxygen species and their detrimental effects on the brain after transient ischemia
have been implicated in the pathogenesis of the ischemic injury. The Kelch-like ECH-…

Burden and coping strategies in mothers of patients with schizophrenia in Japan

…, G Tanaka, H Inadomi, M Urata, Y Ohta - Psychiatry and …, 2008 - Wiley Online Library
Aim: The present study was conducted to identify factors contributing to burden of care in 57
mothers caring for patients with schizophrenia. Methods: Members of the Federation of …

In vivo imaging of autophagy in a mouse stroke model

FF Tian, K Deguchi, T Yamashita, Y Ohta, N Morimoto… - Autophagy, 2010 - Taylor & Francis
Recent studies have suggested that autophagy is involved in a neural death pathway
following cerebral ischemia. In vivo detection of autophagy could be important for evaluating …

Tumorigenic development of induced pluripotent stem cells in ischemic mouse brain

T Yamashita, H Kawai, F Tian, Y Ohta… - Cell …, 2011 - journals.sagepub.com
Induced pluripotent stem (iPS) cells may provide cures for various neurological diseases.
However, undifferentiated iPS cells have high tumorigenicity, and evaluation of the cells fates, …

Atorvastatin and pitavastatin improve cognitive function and reduce senile plaque and phosphorylated tau in aged APP mice

…, K Miyazaki, M Kozuki, VL Panin, N Morimoto, Y Ohta… - Brain research, 2011 - Elsevier
In addition to simply reducing the serum level of cholesterol, 3-hydroxy-3-methyl glutaryl
coenzyme A (HMG-CoA) reductase inhibitors (statins) have various pleiotrophic effects such as …