[HTML][HTML] Gefitinib or chemotherapy for non–small-cell lung cancer with mutated EGFR

…, M Ando, H Miyazawa, T Tanaka, Y Saijo… - … England Journal of …, 2010 - Mass Medical Soc
Background Non–small-cell lung cancer with sensitive mutations of the epidermal growth
factor receptor (EGFR) is highly responsive to EGFR tyrosine kinase inhibitors such as gefitinib…

[PDF][PDF] First-line gefitinib for patients with advanced non-small-cell lung cancer harboring epidermal growth factor receptor mutations without indication for …

…, S Okinaga, I Mikami, M Ando, K Yamazaki, Y Saijo… - J Clin …, 2009 - researchgate.net
Purpose This multicenter phase II study was undertaken to investigate the efficacy and
feasibility of gefitinib for patients with advanced non–small-cell lung cancer (NSCLC) harboring …

[PDF][PDF] Prospective phase II study of gefitinib for chemotherapy-naive patients with advanced non-small-cell lung cancer with epidermal growth factor receptor gene …

…, Y Kimura, N Morikawa, H Watanabe, Y Saijo… - J Clin …, 2006 - researchgate.net
… Akira Inoue, Takuji Suzuki, Tatsuro Fukuhara, Makoto Maemondo, Yuichiro Kimura, Naoto
Morikawa, Hiroshi Watanabe, Yasuo Saijo, and Toshihiro Nukiwa … Financial support: Yasuo …

Severe acute interstitial pneumonia and gefitinib

A Inoue, Y Saijo, M Maemondo, K Gomi, Y Tokue… - The Lancet, 2003 - thelancet.com
Gefitinib is an oral selective inhibitor of the epidermal growth factor receptor tyrosine kinase
that is an effective treatment for patients with advanced non-small cell lung cancer who do …

[HTML][HTML] Infiltration of COX-2–expressing macrophages is a prerequisite for IL-1β–induced neovascularization and tumor growth

…, S Hamano, K Sonoda, Y Saijo… - The Journal of …, 2005 - Am Soc Clin Investig
Inflammatory angiogenesis is a critical process in tumor progression and other diseases. The
inflammatory cytokine IL-1β promotes angiogenesis, tumor growth, and metastasis, but its …

Proinflammatory cytokine IL-1β promotes tumor growth of Lewis lung carcinoma by induction of angiogenic factors: in vivo analysis of tumor-stromal interaction

Y Saijo, M Tanaka, M Miki, K Usui, T Suzuki… - The Journal of …, 2002 - journals.aai.org
Inflammatory conditions are associated with tumor development. IL-1β is a multifunctional
and proinflammatory cytokine that affects nearly all types of cells. To investigate the role of IL-…

[HTML][HTML] Mesenchymal stromal cells promote tumor growth through the enhancement of neovascularization

…, J Itoh, A Umezawa, H Kijima, S Fukuda, Y Saijo - Molecular …, 2011 - Springer
Mesenchymal stromal cells (MSCs), also called mesenchymal stem cells, migrate and function
as stromal cells in tumor tissues. The effects of MSCs on tumor growth are controversial. …

[PDF][PDF] Randomized phase II trial comparing amrubicin with topotecan in patients with previously treated small-cell lung cancer: North Japan Lung Cancer Study Group …

…, H Yokouchi, H Watanabe, T Tsukamoto, Y Saijo… - J Clin Oncol, 2008 - academia.edu
Purpose Amrubicin, a new anthracycline agent, and topotecan are both active for previously
treated small-cell lung cancer (SCLC). No comparative study of these agents has been …

[HTML][HTML] Paracrine factors of multipotent stromal cells ameliorate lung injury in an elastase-induced emphysema model

…, H Xin, M Kanehira, R Sun, T Nukiwa, Y Saijo - Molecular Therapy, 2011 - cell.com
Multipotent stromal cells (MSCs) ameliorate several types of lung injury. The differentiation
of MSCs into specific cells at the injury site has been considered as the important process in …

[HTML][HTML] Methylation of the KEAP1 gene promoter region in human colorectal cancer

…, H Kijima, J Mimura, K Itoh, S Fukuda, Y Saijo - BMC cancer, 2012 - Springer
Background The Keap1-Nrf2 pathway has been reported to be impaired in several cancers.
However, the status of Keap1-Nrf2 system in human colorectal cancer (CRC) has not been …