Background VEGFR-2 has a role in gastric cancer pathogenesis and progression. We assessed
whether ramucirumab, a monoclonal antibody VEGFR-2 antagonist, in combination with …

Background Early clinical trials conducted primarily in Japan have shown that TAS-102, an
oral agent that combines trifluridine and tipiracil hydrochloride, was effective in the treatment …

The number of deaths from colorectal cancer in Japan continues to increase. Colorectal
cancer deaths exceeded 50,000 in 2016. In the 2019 edition, revision of all aspects of …

Background Effective systemic therapies for patients with advanced, progressive neuroendocrine
tumours of the lung or gastrointestinal tract are scarce. We aimed to assess the efficacy …

Japanese mortality due to colorectal cancer is on the rise, surpassing 49,000 in 2015. Many
new treatment methods have been developed during recent decades. The Japanese …

Colorectal cancer is a major cause of death in Japan, where it accounts for the largest number
of deaths from malignant neoplasms in women and the third largest number in men. Many …

Colorectal cancer is a major cause of death in Japan, where it accounts for the largest number
of deaths from malignant neoplasms among women and the third largest number among …

Purpose: To compare fluorouracil (FU) alone with FU plus cisplatin (FP) and with uracil and
tegafur plus mitomycin (UFTM) for patients with advanced gastric cancer in a prospective, …

Diagnostic and treatment strategies for gastrointestinal stromal tumors (GISTs) have evolved
greatly since the introduction of molecularly targeted therapies. Although several clinical …

PURPOSE Adjuvant chemotherapy after hepatectomy is controversial in liver-only metastatic
colorectal cancer (CRC). We conducted a randomized controlled trial to examine if …