Genome-wide mutational signatures of aristolochic acid and its application as a screening tool

…, W Yu, KK Huang, P Guan, WH Weng… - Science translational …, 2013 - science.org
Aristolochic acid (AA), a natural product of Aristolochia plants found in herbal remedies and
health supplements, is a group 1 carcinogen that can cause nephrotoxicity and upper …

Loss of tumor suppressor KDM6A amplifies PRC2-regulated transcriptional repression in bladder cancer and can be targeted through inhibition of EZH2

…, PH Lin, CK Chuang, YH Chang, WH Weng… - Science translational …, 2017 - science.org
Trithorax-like group complex containing KDM6A acts antagonistically to Polycomb-repressive
complex 2 (PRC2) containing EZH2 in maintaining the dynamics of the repression and …

[HTML][HTML] Mutation signatures implicate aristolochic acid in bladder cancer development

…, A Gan, SS Myint, EY Siew, LD Ler, LG Ng, WH Weng… - Genome medicine, 2015 - Springer
Background Aristolochic acid (AA) is a natural compound found in many plants of the
Aristolochia genus, and these plants are widely used in traditional medicines for numerous …

Prognostic impact of immunohistochemical expression of ezrin in highly malignant soft tissue sarcomas

WH Weng, J Åhlén, K Åström, WO Lui… - Clinical Cancer …, 2005 - AACR
Purpose: Ezrin is a cytoskeleton linker protein that is actively involved in regulating the
growth and metastatic capacity of cancer cells. It has recently been reported to be involved in …

Insulin-like growth factor type 1 receptor expression correlates to good prognosis in highly malignant soft tissue sarcoma

…, J Wejde, O Brosjö, A Von Rosen, WH Weng… - Clinical cancer …, 2005 - AACR
Purpose: To evaluate known and suggested prognostic markers, especially insulin-like
growth factor type 1 receptor (IGF-1R), in highly malignant soft tissue sarcomas (STS). …

Glucose/glutathione co-triggered tumor hypoxia relief and Chemodynamic therapy to enhance Photothermal therapy in bladder cancer

…, KJ Yu, JW Jhou, HH Pang, WH Weng… - ACS Applied Bio …, 2021 - ACS Publications
Photothermal therapy (PTT) is a potential treatment for cancer that makes use of near-infrared
(NIR) laser irradiation and is expected to assist traditional anti-cancer drug therapies; …

[HTML][HTML] High-sensitivity dual-probe detection of urinary miR-141 in cancer patients via a modified screen-printed carbon electrode-based electrochemical biosensor

…, SX Weng, YL Lin, YE Chiou, ST Pang, WH Weng - Sensors, 2021 - mdpi.com
The screening and diagnosis of cancer are hallmarks of medicine in the aging population.
Recently, microRNAs have shown potential for use as biomarkers, which could advance the …

Combined detection of cancer cells and a tumor biomarker using an immunomagnetic sensor for the improvement of prostate-cancer diagnosis

…, SS Liao, YT Chen, HC Chen, WH Weng… - Advanced …, 2014 - ntut.elsevierpure.com
Capture and detection of both a relevant antigen and cancer cells are demonstrated using
magnetic graphene oxide (MGO) possessing conjugated antibodies. By simply dropping the …

[HTML][HTML] Lauric acid can improve the sensitization of Cetuximab in KRAS/BRAF mutated colorectal cancer cells by retrievable microRNA-378 expression

WH Weng, WH Leung, YJ Pang… - Oncology …, 2016 - spandidos-publications.com
EGFR-inhibitor (Cetuximab) is one of the main targeted drugs used for metastatic colorectal
carcinoma (CRC). The benefit from Cetuximab appears to be limited to a subtype of patients, …

[PDF][PDF] Neuregulin/erythroblastic leukemia viral oncogene homolog 3 autocrine loop contributes to invasion and early recurrence of human hepatoma

…, TC Shih, MC Yu, YJ Lin, CJ Chang, WH Weng… - …, 2011 - Wiley Online Library
Intrahepatic metastasis is the primary cause of the high recurrence and poor prognosis of
human hepatocellular carcinoma (HCC). However, neither its molecular mechanisms nor …