User profiles for WEI-CHIEN HUANG
Wei-Chien HuangGraduate Institute of Biomedical Sciences, China Medical University Verified email at mail.cmu.edu.tw Cited by 7014 |
[HTML][HTML] IKKβ suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway
TNFα has recently emerged as a regulator linking inflammation to cancer pathogenesis, but
the detailed cellular and molecular mechanisms underlying this link remain to be elucidated. …
the detailed cellular and molecular mechanisms underlying this link remain to be elucidated. …
ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation
The RAS–ERK pathway is known to play a pivotal role in differentiation, proliferation and
tumour progression. Here, we show that Erk downregulates Forkhead box O 3a (FOXO3a) by …
tumour progression. Here, we show that Erk downregulates Forkhead box O 3a (FOXO3a) by …
[HTML][HTML] Survival of cancer cells is maintained by EGFR independent of its kinase activity
Z Weihua, R Tsan, WC Huang, Q Wu, CH Chiu… - Cancer cell, 2008 - cell.com
Expression of the epidermal growth factor receptor (EGFR), a receptor tyrosine kinase
associated with cell proliferation and survival, is overactive in many tumors of epithelial origin. …
associated with cell proliferation and survival, is overactive in many tumors of epithelial origin. …
Flavonoids inhibit tumor necrosis factor-α-induced up-regulation of intercellular adhesion molecule-1 (ICAM-1) in respiratory epithelial cells through activator protein-1 …
CC Chen, MP Chow, WC Huang, YC Lin… - Molecular pharmacology, 2004 - ASPET
Intercellular adhesion molecule-1 (ICAM-1) has been implicated in the processes of
inflammation and carcinogenesis. Flavonoids, which are polyphenolic compounds with a wide …
inflammation and carcinogenesis. Flavonoids, which are polyphenolic compounds with a wide …
Akt phosphorylation of p300 at Ser-1834 is essential for its histone acetyltransferase and transcriptional activity
WC Huang, CC Chen - Molecular and cellular biology, 2005 - Taylor & Francis
The PI3K/Akt pathway plays a critical role in the regulation of gene expression induced by
numerous stimuli. p300, a transcriptional coactivator, acts in concert with transcription factors …
numerous stimuli. p300, a transcriptional coactivator, acts in concert with transcription factors …
[PDF][PDF] Phosphorylation of CBP by IKKα promotes cell growth by switching the binding preference of CBP from p53 to NF-κB
CBP plays a central role in coordinating and integrating multiple signaling pathways. Competition
between NF-κB and p53 for CBP is a crucial determinant of whether a cell proliferates …
between NF-κB and p53 for CBP is a crucial determinant of whether a cell proliferates …
[HTML][HTML] Nuclear translocation of epidermal growth factor receptor by Akt-dependent phosphorylation enhances breast cancer-resistant protein expression in gefitinib …
Epidermal growth factor receptor (EGFR), an aberrantly overexpressed or activated receptor-tyrosine
kinase in many cancers, plays a pivotal role in cancer progression and has been …
kinase in many cancers, plays a pivotal role in cancer progression and has been …
[HTML][HTML] Hesperidin is a potential inhibitor against SARS-CoV-2 infection
Hesperidin (HD) is a common flavanone glycoside isolated from citrus fruits and possesses
great potential for cardiovascular protection. Hesperetin (HT) is an aglycone metabolite of …
great potential for cardiovascular protection. Hesperetin (HT) is an aglycone metabolite of …
P300 acetyltransferase mediates stiffness-induced activation of hepatic stellate cells into tumor-promoting myofibroblasts
Background & Aims Hepatic stellate cells (HSCs) contribute to desmoplasia and stiffness of
liver metastases by differentiating into matrix-producing myofibroblasts. We investigated …
liver metastases by differentiating into matrix-producing myofibroblasts. We investigated …
[HTML][HTML] Induction of Akt activity by chemotherapy confers acquired resistance
Resistance to chemotherapy is a major cause of treatment failure in human cancer. Accumulating
evidence has indicated that the acquisition of resistance to chemotherapeutic drugs …
evidence has indicated that the acquisition of resistance to chemotherapeutic drugs …