TNFα has recently emerged as a regulator linking inflammation to cancer pathogenesis, but
the detailed cellular and molecular mechanisms underlying this link remain to be elucidated. …

The RAS–ERK pathway is known to play a pivotal role in differentiation, proliferation and
tumour progression. Here, we show that Erk downregulates Forkhead box O 3a (FOXO3a) by …

Expression of the epidermal growth factor receptor (EGFR), a receptor tyrosine kinase
associated with cell proliferation and survival, is overactive in many tumors of epithelial origin. …

Intercellular adhesion molecule-1 (ICAM-1) has been implicated in the processes of
inflammation and carcinogenesis. Flavonoids, which are polyphenolic compounds with a wide …

The PI3K/Akt pathway plays a critical role in the regulation of gene expression induced by
numerous stimuli. p300, a transcriptional coactivator, acts in concert with transcription factors …

CBP plays a central role in coordinating and integrating multiple signaling pathways. Competition
between NF-κB and p53 for CBP is a crucial determinant of whether a cell proliferates …

Epidermal growth factor receptor (EGFR), an aberrantly overexpressed or activated receptor-tyrosine
kinase in many cancers, plays a pivotal role in cancer progression and has been …

Hesperidin (HD) is a common flavanone glycoside isolated from citrus fruits and possesses
great potential for cardiovascular protection. Hesperetin (HT) is an aglycone metabolite of …

Background & Aims Hepatic stellate cells (HSCs) contribute to desmoplasia and stiffness of
liver metastases by differentiating into matrix-producing myofibroblasts. We investigated …

Resistance to chemotherapy is a major cause of treatment failure in human cancer. Accumulating
evidence has indicated that the acquisition of resistance to chemotherapeutic drugs …