Bortezomib is a new proteasome inhibitor with a high antitumor activity, but also with a
potentially severe peripheral neurotoxicity. To establish a preclinical model and to characterize …

BACKGROUND: Reelin and GAD 67 expression is downregulated in cortical interneurons
of schizophrenia (SZ) patients. This downregulation is probably mediated by epigenetic …

The clinical usability of pancreatic islet transplantation for the treatment of type I diabetes,
despite some encouraging results, is currently hampered by the short lifespan of the …

Alzheimer's disease (AD) is often accompanied by extrapyramidal signs attributed to
nigrostriatal dysfunction. The association between amyloid deposition and nigrostriatal …

Chemotherapy-induced peripheral neuropathy (CIPN) is a major cause of disability in
cancer survivors. CIPN investigations in preclinical model systems have focused on either …

Purpose: Antineoplastic drugs, such as cisplatin (CDDP), are severely neurotoxic, causing
disabling peripheral neuropathies with clinical signs known as chemotherapy-induced …

Background Chemotherapy-induced peripheral neurotoxicity (CIPN) is a severe adverse
effect in patients receiving antitumor agents, and no effective treatment is available. Although …

Aging is associated with an exaggerated response to peripheral inflammatory challenges
together with behavioral and cognitive deficits. Studies considering both age and sex remain …

Oxaliplatin (OHP) Induced Peripheral Neurotoxicity (OIPN) is one of the dose-limiting toxicities
of the drug and these adverse effects limit cancer therapy with L-OHP, used for colorectal …

Despite the different antineoplastic mechanisms of action, peripheral neurotoxicity induced
by all chemotherapy drugs (anti-tubulin agents, platinum compounds, proteasome inhibitors, …