Immunohistochemical and genetic evaluation of deoxycytidine kinase in pancreatic cancer: relationship to molecular mechanisms of gemcitabine resistance and …

V Sebastiani, F Ricci, B Rubio-Viquiera, P Kulesza… - Clinical Cancer …, 2006 - AACR
Gemcitabine is considered the standard first-line therapy for patients with advanced pancreatic
cancer. More recent strategies have focused on improving the efficacy of gemcitabine by …

Fatty acid synthase (FAS) is a marker of increased risk of recurrence in lung carcinoma

P Visca, V Sebastiani, C Botti, MG Diodoro… - Anticancer …, 2004 - ar.iiarjournals.org
Background: We explored the expression of Fatty Acid Synthase (FAS) in lung carcinomas
and its association with clinico-pathological features and prognosis. FAS is a recently …

Epidermal growth factor receptor dynamics influences response to epidermal growth factor receptor targeted agents

…, N Bouraoud, P Kulesza, V Sebastiani… - Cancer research, 2005 - AACR
Abstract Analysis of gene expression of cancer cell lines exposed to erlotinib, a small molecule
inhibitor of the epidermal growth factor receptor (EGFR), showed a marked increase in …

Immnunohistochemical expression and prognostic significance of fatty acid synthase in pancreatic carcinoma

…, M Amini, F Piro, L Pizzuti, V Sebastiani… - Anticancer …, 2007 - ar.iiarjournals.org
Background: The aim of this study was to evaluate immunohistochemical markers in
pancreatic cancer and to determine the association of their expression with clinico-pathological …

Fatty acid synthase is a marker of increased risk of recurrence in endometrial carcinoma

V Sebastiani, P Visca, C Botti, G Santeusanio… - Gynecologic …, 2004 - Elsevier
Purpose. To explore the expression of fatty acid synthase (FAS) and human erythrocyte
glucose transporter 1 (GLUT1) in endometrial carcinomas and to detect associations with …

Immunohistochemical expression of human erythrocyte glucose transporter and fatty acid synthase in infiltrating breast carcinomas and adjacent typical/atypical …

…, P Visca, C Botti, GM Galati, V Sebastiani… - American journal of …, 2001 - academic.oup.com
To evaluate the immunohistochemical expression of GLUT1, human erythrocyte glucose
transporter 1, and fatty acid synthase (FAS), 66 human breast carcinomas and adjacent …

Immunohistochemical study of fatty acid synthase in ovarian neoplasms.

…, C Botti, S Monaco, V Sebastiani… - Oncology …, 2000 - spandidos-publications.com
In order to evaluate the prognostic significance of fatty acid synthase (FAS), the key enzyme
in fatty acid biosynthesis, in ovarian benign and malignant tumors 98 patients with ovarian …

Immunohistochemical expression and prognostic significance of FAS and GLUT1 in bladder carcinoma.

P Visca, V Sebastiani, ES Pizer, C Botti… - Anticancer …, 2003 - europepmc.org
Background Fatty Acid Synthase (FAS) and Human Erythrocyte Glucose Transporter 1 (GLUT1)
are new markers involved in the biological activities of cancer cells. FAS is a …

Assessment of epidermal growth factor receptor (EGFR) signaling in paired colorectal cancer and normal colon tissue samples using computer-aided …

…, D Oppenheimer, J Peralba, V Sebastiani… - Cancer biology & …, 2005 - Taylor & Francis
The Epidermal Growth Factor Receptor (EGFR) plays a role in multiple tumor cell processes
and is targeted by several anticancer therapies. Although EGFR mutations determine tumor …

Role and prognostic significance of CD44s expression in colorectal cancer.

…, C Botti, F Marandino, V Sebastiani… - Anticancer …, 2002 - europepmc.org
Materials and methods CD44s immunohistochemical expression was evaluated in 100
patients with colon adenoma and 100 patients with colon adenocarcinoma and adjacent non-…