The casein kinase 1 family: participation in multiple cellular processes in eukaryotes
U Knippschild, A Gocht, S Wolff, N Huber, J Löhler… - Cellular signalling, 2005 - Elsevier
Phosphorylation of serine, threonine and tyrosine residues by cellular protein kinases plays
an important role in the regulation of various cellular processes. The serine/threonine …
an important role in the regulation of various cellular processes. The serine/threonine …
T-lymphocyte infiltration in visceral adipose tissue: a primary event in adipose tissue inflammation and the development of obesity-mediated insulin resistance
…, T Unger, AM Wolf, U Knippschild… - … , and vascular biology, 2008 - Am Heart Assoc
Background— Adipose tissue inflammation may play a critical role in the pathogenesis of
insulin resistance (IR). The present study examined the role of lymphocytes in adipose tissue …
insulin resistance (IR). The present study examined the role of lymphocytes in adipose tissue …
Obesity-induced overexpression of miR-802 impairs glucose metabolism through silencing of Hnf1b
…, L Scheja, C Haumaitre, AM Wolf, U Knippschild… - Nature, 2013 - nature.com
Insulin resistance represents a hallmark during the development of type 2 diabetes mellitus
and in the pathogenesis of obesity-associated disturbances of glucose and lipid metabolism …
and in the pathogenesis of obesity-associated disturbances of glucose and lipid metabolism …
[HTML][HTML] The stem cell-associated Hiwi gene in human adenocarcinoma of the pancreas: expression and risk of tumour-related death
…, T Greither, H Taubert, P Möller, U Knippschild… - British journal of …, 2008 - nature.com
Piwi proteins and their interaction with piRNAs have rapidly emerged as important contributors
to gene regulation, indicating their crucial function in germline and stem cell development…
to gene regulation, indicating their crucial function in germline and stem cell development…
[HTML][HTML] De novo lipogenesis in human fat and liver is linked to ChREBP-β and metabolic health
L Eissing, T Scherer, K Tödter, U Knippschild… - Nature …, 2013 - nature.com
Clinical interest in de novo lipogenesis has been sparked by recent studies in rodents
demonstrating that de novo lipogenesis specifically in white adipose tissue produces the insulin-…
demonstrating that de novo lipogenesis specifically in white adipose tissue produces the insulin-…
[HTML][HTML] The CK1 family: contribution to cellular stress response and its role in carcinogenesis
U Knippschild, M Krüger, J Richter, P Xu… - Frontiers in …, 2014 - frontiersin.org
Members of the highly conserved and ubiquitously expressed pleiotropic CK1 family play
major regulatory roles in many cellular processes including DNA-processing and repair, …
major regulatory roles in many cellular processes including DNA-processing and repair, …
Posttranslational modification of MDM2
DW Meek, U Knippschild - Molecular cancer research, 2003 - AACR
The functions of the MDM2 protein, in particular its E3 ubiquitin ligase activity and its ability
to interact with a number of cellular proteins intimately involved in growth regulation, are …
to interact with a number of cellular proteins intimately involved in growth regulation, are …
The role of the casein kinase 1 (CK1) family in different signaling pathways linked to cancer development
U Knippschild, S Wolff, G Giamas… - Oncology Research …, 2005 - karger.com
The members of the casein kinase 1 (CK1) family are highly conserved and are expressed
in many eukaryotes ranging from yeast to humans. Mammalian CK1 isoforms (a, ß, ?, d, e) …
in many eukaryotes ranging from yeast to humans. Mammalian CK1 isoforms (a, ß, ?, d, e) …
[PDF][PDF] Brain insulin lowers circulating BCAA levels by inducing hepatic BCAA catabolism
…, PJ White, AL Lapworth, O Ilkayeva, U Knippschild… - Cell metabolism, 2014 - cell.com
Circulating branched-chain amino acid (BCAA) levels are elevated in obesity/diabetes and
are a sensitive predictor for type 2 diabetes. Here we show in rats that insulin dose-…
are a sensitive predictor for type 2 diabetes. Here we show in rats that insulin dose-…
Kinases as targets in the treatment of solid tumors
…, K Khan, SSL Ahmed, J Stebbing, U Knippschild - Cellular signalling, 2010 - Elsevier
The protein kinase family, one of the largest gene families in eukaryotes, plays an important
role in regulating various cellular processes such as cell proliferation, cell death, cell cycle …
role in regulating various cellular processes such as cell proliferation, cell death, cell cycle …