The casein kinase 1 family: participation in multiple cellular processes in eukaryotes

U Knippschild, A Gocht, S Wolff, N Huber, J Löhler… - Cellular signalling, 2005 - Elsevier
Phosphorylation of serine, threonine and tyrosine residues by cellular protein kinases plays
an important role in the regulation of various cellular processes. The serine/threonine …

T-lymphocyte infiltration in visceral adipose tissue: a primary event in adipose tissue inflammation and the development of obesity-mediated insulin resistance

…, T Unger, AM Wolf, U Knippschild… - … , and vascular biology, 2008 - Am Heart Assoc
Background— Adipose tissue inflammation may play a critical role in the pathogenesis of
insulin resistance (IR). The present study examined the role of lymphocytes in adipose tissue …

Obesity-induced overexpression of miR-802 impairs glucose metabolism through silencing of Hnf1b

…, L Scheja, C Haumaitre, AM Wolf, U Knippschild… - Nature, 2013 - nature.com
Insulin resistance represents a hallmark during the development of type 2 diabetes mellitus
and in the pathogenesis of obesity-associated disturbances of glucose and lipid metabolism …

[HTML][HTML] The stem cell-associated Hiwi gene in human adenocarcinoma of the pancreas: expression and risk of tumour-related death

…, T Greither, H Taubert, P Möller, U Knippschild… - British journal of …, 2008 - nature.com
Piwi proteins and their interaction with piRNAs have rapidly emerged as important contributors
to gene regulation, indicating their crucial function in germline and stem cell development…

[HTML][HTML] De novo lipogenesis in human fat and liver is linked to ChREBP-β and metabolic health

L Eissing, T Scherer, K Tödter, U Knippschild… - Nature …, 2013 - nature.com
Clinical interest in de novo lipogenesis has been sparked by recent studies in rodents
demonstrating that de novo lipogenesis specifically in white adipose tissue produces the insulin-…

[HTML][HTML] The CK1 family: contribution to cellular stress response and its role in carcinogenesis

U Knippschild, M Krüger, J Richter, P Xu… - Frontiers in …, 2014 - frontiersin.org
Members of the highly conserved and ubiquitously expressed pleiotropic CK1 family play
major regulatory roles in many cellular processes including DNA-processing and repair, …

Posttranslational modification of MDM2

DW Meek, U Knippschild - Molecular cancer research, 2003 - AACR
The functions of the MDM2 protein, in particular its E3 ubiquitin ligase activity and its ability
to interact with a number of cellular proteins intimately involved in growth regulation, are …

The role of the casein kinase 1 (CK1) family in different signaling pathways linked to cancer development

U Knippschild, S Wolff, G Giamas… - Oncology Research …, 2005 - karger.com
The members of the casein kinase 1 (CK1) family are highly conserved and are expressed
in many eukaryotes ranging from yeast to humans. Mammalian CK1 isoforms (a, ß, ?, d, e) …

[PDF][PDF] Brain insulin lowers circulating BCAA levels by inducing hepatic BCAA catabolism

…, PJ White, AL Lapworth, O Ilkayeva, U Knippschild… - Cell metabolism, 2014 - cell.com
Circulating branched-chain amino acid (BCAA) levels are elevated in obesity/diabetes and
are a sensitive predictor for type 2 diabetes. Here we show in rats that insulin dose-…

Kinases as targets in the treatment of solid tumors

…, K Khan, SSL Ahmed, J Stebbing, U Knippschild - Cellular signalling, 2010 - Elsevier
The protein kinase family, one of the largest gene families in eukaryotes, plays an important
role in regulating various cellular processes such as cell proliferation, cell death, cell cycle …