Colorectal cancer (CRC) is one of the most common and deadly forms of cancer. Despite
improved treatment modalities, post-operative recurrence and metastasis remain the major …

Objective In IBD, interleukin-23 (IL-23) and its receptor (IL-23R) are implicated in disease
initiation and progression. Novel insight into which cells produce IL-23 at the site of …

Background Vitamin D deficiency is a risk factor for inflammatory bowel disease (IBD). The IL-23–driven
tissue-resident group 3 innate lymphoid cells (ILC3s) play essential roles in …

Background Approximately 15 to 30% of colorectal cancers present as an emergency, most
often as obstruction or perforation. Studies report poorer outcome for patients who undergo …

Human innate lymphoid cells have been described to exist in different organs, with functional
deregulation of these cells contributing to several disease states. Here, we performed the …

Background Studies of colorectal cancer (CRC) have suggested different mechanisms of
carcinogenesis in men and women, young and old patients, right- and left sided tumors, and …

Innate lymphoid cells (ILCs) are highly plastic and predominantly mucosal tissue-resident cells
that contribute to both homeostasis and inflammation depending on the microenvironment…

ILCs and T helper cells have been shown to exert bi-directional regulation in mice. However,
how crosstalk between ILCs and CD4 + T cells influences immune function in humans is …

Purpose To identify factors associated with timing of stoma reversal after rectal cancer surgery
in a large Swedish register-based cohort. Methods Three thousand five hundred sixty-four …

The genetic susceptibility to colorectal cancer (CRC) has been estimated to be around 35%
and yet high-penetrance germline mutations found so far explain less than 5% of all cases. …