Regulation of fatty acid oxidation in the mammalian heart in health and disease
GD Lopaschuk, DD Belke, J Gamble, I Toshiyuki… - … et Biophysica Acta (BBA …, 1994 - Elsevier
… Belke, Jim Gamble, Toshiyuki Itoi, Brett 0. Schijnekess …
Developmental changes in energy substrate use by the heart
…, RL Collins-Nakai, T Itoi - Cardiovascular research, 1992 - academic.oup.com
Marked changes in intermediary metabolism occur during development of the heart. In the
fetus, the heart utilises lactate and glucose as its main energy substrates, while in the adult, …
fetus, the heart utilises lactate and glucose as its main energy substrates, while in the adult, …
Acetyl-CoA carboxylase involvement in the rapid maturation of fatty acid oxidation in the newborn rabbit heart.
GD Lopaschuk, LA Witters, T Itoi, R Barr… - Journal of Biological …, 1994 - Elsevier
Fatty acid oxidation rapidly increases in the rabbit heart following birth. By inhibiting carnitine
palmitoyltransferase 1 (CPT1), malonyl-CoA is a potent regulator of fatty acid oxidation in …
palmitoyltransferase 1 (CPT1), malonyl-CoA is a potent regulator of fatty acid oxidation in …
Adoptive transfer of macrophages ameliorates renal fibrosis in mice
…, Y Okumura, S Fujimoto, I Shiraishi, T Itoi… - Biochemical and …, 2005 - Elsevier
We performed adoptive transfer of bone marrow-derived (BM) macrophages following
pharmacological depletion of leukocytes in a mouse model of unilateral ureteral obstruction (UUO)…
pharmacological depletion of leukocytes in a mouse model of unilateral ureteral obstruction (UUO)…
MMP-2 inhibition reduces renal macrophage infiltration with increased fibrosis in UUO
…, Y Okumura, S Ozawa, I Shiraishi, T Itoi… - Biochemical and …, 2007 - Elsevier
We examined the role of matrix metalloproteinase-2 (MMP-2) in renal fibrosis and its effect
on interstitial macrophage infiltration in a mouse model of unilateral ureteral obstruction (UUO)…
on interstitial macrophage infiltration in a mouse model of unilateral ureteral obstruction (UUO)…
The contribution of glycolysis, glucose oxidation, lactate oxidation, and fatty acid oxidation to ATP production in isolated biventricular working hearts from 2-week-old …
T Itoi, GD Lopaschuk - Pediatric research, 1993 - nature.com
ABSTRACT: Immediately after birth, glycolysis and lactate oxidation are the major source of
ATP production in the rabbit heart. Although the ability of heart to oxidize fatty acid increases …
ATP production in the rabbit heart. Although the ability of heart to oxidize fatty acid increases …
[HTML][HTML] The role of apelin on the alleviative effect of Angiotensin receptor blocker in unilateral ureteral obstruction-induced renal fibrosis
…, Y Okumura, T Oka, K Toiyama, S Ozawa, T Itoi… - Nephron extra, 2012 - karger.com
Background: Apelin is a selective endogenous ligand of the APJ receptor, which genetically
has closest identity to the angiotensin II type 1 receptor (AT-1). The effects of the apelin/APJ …
has closest identity to the angiotensin II type 1 receptor (AT-1). The effects of the apelin/APJ …
Matrix metalloproteinase-9 in vascular lesions and endothelial regulation in Kawasaki disease
…, M Fujii, A Hamaoka, K Toiyama, M Nishida, T Itoi - Circulation …, 2010 - jstage.jst.go.jp
Background: Matrix metalloproteinases (MMPs) contribute to extracellular remodeling in
Kawasaki disease (KD). MMP-9 is an essential vasculature-remodeling factor but its role in the …
Kawasaki disease (KD). MMP-9 is an essential vasculature-remodeling factor but its role in the …
OnabotulinumtoxinA (botulinum toxin type A) for the treatment of Japanese patients with overactive bladder and urinary incontinence: results of single‐dose treatment …
…, F Nakajima, H Sasaki, N Okuno, T Itoi… - … Journal of Urology, 2020 - Wiley Online Library
Objective To evaluate the efficacy and safety of onabotulinumtoxinA (botulinum toxin type A)
100 U in patients with overactive bladder and urinary incontinence. Methods This was a …
100 U in patients with overactive bladder and urinary incontinence. Methods This was a …
Efficacy and safety of tolvaptan for pediatric patients with congestive heart failure. Multicenter survey in the working group of the Japanese Society of PEdiatric …
K Higashi, T Murakami, Y Ishikawa, T Itoi… - International journal of …, 2016 - Elsevier
Background Tolvaptan, a vasopressin V2-receptor antagonist, has been reported to improve
congestion in adult patients with heart failure. However, it has not been fully clarified …
congestion in adult patients with heart failure. However, it has not been fully clarified …