Mediation of Unusually High Concentrations of 1,25-Dihydroxyvitamin D in Homozygous klotho Mutant Mice by Increased Expression of Renal 1α-Hydroxylase Gene

T Yoshida, T Fujimori, YI Nabeshima - Endocrinology, 2002 - academic.oup.com
Homozygous klotho mutant (kl−/−) mice exhibit multiple phenotypes resembling human
aging. To elucidate the molecular basis of these singular phenotypes, we focused on the …

Antiandrogen bicalutamide promotes tumor growth in a novel androgen-dependent prostate cancer xenograft model derived from a bicalutamide-treated patient

T Yoshida, H Kinoshita, T Segawa, E Nakamura… - Cancer research, 2005 - AACR
Androgen ablation therapies are effective in controlling prostate cancer. Although most
cancers relapse and progress despite androgen ablation, some patients experience …

A structural and functional perspective of DyP-type peroxidase family

T Yoshida, Y Sugano - Archives of biochemistry and biophysics, 2015 - Elsevier
Dye-decolorizing peroxidase from the basidiomycete Bjerkandera adusta Dec 1 (DyP) is a
heme peroxidase. This name reflects its ability to degrade several anthraquinone dyes. The …

[HTML][HTML] Usefulness of blood supply visualization by indocyanine green fluorescence for reconstruction during esophagectomy

…, S Sawada, K Matsui, R Hori, I Yoshioka, T Yoshida… - Esophagus, 2011 - Springer
Background Adequate blood supply for the reconstructed organ is important for safe
esophagogastric anastomosis during esophagectomy. Recently, indocyanine green (ICG) has been …

Development of gastric carcinoma from intestinal metaplasia in Cdx2-transgenic mice

…, Y Sato, H Yamamoto, N Isoda, T Yoshida… - Cancer research, 2004 - AACR
In the progression of chronic gastritis, gastric mucosal cells deviate from the normal pathway
of gastric differentiation to an intestinal phenotype. Many epidemiologic studies have found …

Five-year survival outcomes of laparoscopy-assisted vs open distal gastrectomy for advanced gastric cancer: the JLSSG0901 randomized clinical trial

…, S Sakuramoto, T Tsuji, SW Lee, K Yoshida… - JAMA …, 2023 - jamanetwork.com
Importance Evidence of implementation of laparoscopic gastrectomy for locally advanced
gastric cancer is currently insufficient, as the primary end point in previous prospective studies …

Increased transcription of the astrocyte gene GFAP during middle-age is attenuated by food restriction: implications for the role of oxidative stress

…, I Rozovsky, SK Goldsmith, DJ Stone, T Yoshida… - Free radical biology and …, 1997 - Elsevier
Glial fibrillary acidic protein (GFAP), an intermediate filament of astrocytes, shows increased
expression during aging. Because we found that chronic food restriction retards the …

[HTML][HTML] DyP-type peroxidases: recent advances and perspectives

Y Sugano, T Yoshida - International Journal of Molecular Sciences, 2021 - mdpi.com
In this review, we chart the major milestones in the research progress on the DyP-type
peroxidase family over the past decade. Though mainly distributed among bacteria and fungi, this …

The catalytic mechanism of dye‐decolorizing peroxidase DyP may require the swinging movement of an aspartic acid residue

T Yoshida, H Tsuge, H Konno, T Hisabori… - The FEBS …, 2011 - Wiley Online Library
The dye‐decolorizing peroxidase (DyP)‐type peroxidase family is a unique heme peroxidase
family. The primary and tertiary structures of this family are obviously different from those of …

Microsatellite instability and mutation of mitochondrial and nuclear DNA in gastric carcinoma

…, T Sugai, SI Nakamura, N Uesugi, T Yoshida… - Gastroenterology, 2000 - Elsevier
Background & Aims: Microsatellite instability (MSI) in mitochondrial DNA (mtDNA) is
observed in some colorectal carcinomas. We attempted to determine if mitochondrial MSI (mtMSI) …