Purpose: To evaluate the preclinical pharmacokinetics and antitumor efficacy of a novel
orally bioavailable poly(ADP-ribose) polymerase (PARP) inhibitor, ABT-888. Experimental …

The Akt kinases are central nodes in signal transduction pathways that are important for
cellular transformation and tumor progression. We report the development of a series of potent …

Progress in understanding tumor stromal biology has been constrained in part because
cancer-associated fibroblasts (CAF) are a heterogeneous population with limited cell-type–…

Many established cancer therapies involve DNA-damaging chemotherapy or radiotherapy.
Gain of DNA repair capacity of the tumor represents a common mechanism used by cancer …

The BGL2 gene encodes a unique 1,3-β-glucosyltransferase (BgI2p) present in the cell wall
of Candida albicans and other fungi. Although believed to be involved in cell wall assembly, …

Survivin, one of the most tumor-specific gene products, has been implicated in both anti-apoptosis
and cytokinesis. However, the mechanism by which survivin regulates these two …

Improving the congruity of preclinical models with cancer as it is manifested in humans is a
potential way to mitigate the high attrition rate of new cancer therapies in the clinic. In this …

Akt (PKB) is a serine/threonine protein kinase that plays an important role in the transduction
of signals affecting apoptosis, cell proliferation and survival. The Akt gene is frequently …

The Bcl‐2 family inhibitors venetoclax and navitoclax demonstrated potent antitumor activity
in chronic lymphocytic leukemia patients, notably in reducing marrow load and adenopathy. …

Akt is a serine/threonine kinase that transduces survival signals from survival/growth factors.
Deregulation and signal imbalance in cancer cells make them prone to apoptosis. …