Anti-cell growth and anti-cancer stem cell activities of the non-canonical hedgehog inhibitor GANT61 in triple-negative breast cancer cells

Y Koike, Y Ohta, W Saitoh, T Yamashita, N Kanomata… - Breast Cancer, 2017 - Springer
Background Triple-negative breast cancer (TNBC) exhibits biologically aggressive behavior
and has a poor prognosis. Novel molecular targeting agents are needed to control TNBC. …

Anti‐cancer stem cell activity of a hedgehog inhibitor GANT 61 in estrogen receptor‐positive breast cancer cells

…, Y Koike, Y Ohta, W Saitoh, T Yamashita… - Cancer …, 2017 - Wiley Online Library
Estradiol (E2) increases not only the cell growth but also the cancer stem cell ( CSC ) proportion
in estrogen receptor ( ER )‐positive breast cancer cells. It has been suggested that the …

[HTML][HTML] Systemic immunity markers associated with lymphocytes predict the survival benefit from paclitaxel plus bevacizumab in HER2 negative advanced breast …

…, M Ikeda, S Kubo, M Yamamoto, T Yamashita… - Scientific Reports, 2021 - nature.com
Although paclitaxel plus bevacizumab (PB) therapy is an effective chemotherapeutic regimen
for HER2-negative advanced breast cancer (ABC), predictive markers for its effectiveness …

Dynamic changes in absolute lymphocyte counts during eribulin therapy are associated with survival benefit

…, M Ikeda, S Kubo, M Yamamoto, T Yamashita - Anticancer …, 2021 - ar.iiarjournals.org
Background/Aim: We investigated the usefulness of dynamic changes in absolute lymphocyte
count (ALC) and neutrophil-to-lymphocyte ratio (NLR) during eribulin therapy as predictive …

Antitumor and anticancer stem cell activity of a poly ADP-ribose polymerase inhibitor olaparib in breast cancer cells

T Shimo, J Kurebayashi, N Kanomata, T Yamashita… - Breast Cancer, 2014 - Springer
Background Although the poly adenosine diphosphate (ADP)-ribose polymerase (PARP)
inhibitor olaparib is known to have potent antitumor activity in BRCA-related breast cancer cells…

Antitumor and anticancer stem cell activities of eribulin mesylate and antiestrogens in breast cancer cells

J Kurebayashi, N Kanomata, T Yamashita, T Shimo… - Breast Cancer, 2016 - Springer
Background Eribulin mesylate (eribulin), a non-taxane microtubule dynamic inhibitor, has
been widely used in the treatment of patients with advanced or metastatic breast cancer. The …

Marked lymphovascular invasion, progesterone receptor negativity, and high Ki67 labeling index predict poor outcome in breast cancer patients treated with …

J Kurebayashi, N Kanomata, T Shimo, T Yamashita… - Breast Cancer, 2014 - Springer
Purpose Whether postoperative chemotherapy should be added to endocrine therapy or not
is an important issue in patients with hormone receptor-positive and human epidermal …

[HTML][HTML] Targeted next-generation sequencing assays using triplet samples of normal breast tissue, primary breast cancer, and recurrent/metastatic lesions

T Akahane, N Kanomata, O Harada, T Yamashita… - BMC cancer, 2020 - Springer
Background Next-generation sequencing (NGS) has shown that recurrent/metastatic breast
cancer lesions may have additional genetic changes compared with the primary tumor. …

Prognostic value of phosphorylated HER2 in HER2-positive breast cancer patients treated with adjuvant trastuzumab

J Kurebayashi, N Kanomata, T Yamashita, T Shimo… - Breast cancer, 2015 - Springer
Background Adjuvant trastuzumab has been routinely used in HER2-positive operable breast
cancer patients. Prognostic factors remain to be well characterized in these patients and …

Percutaneous transluminal angioplasty for central venous disease in dialysis patients: influence on cardiac function

…, S Shintaku, M Moriishi, T Yamashita… - The Journal of …, 2014 - journals.sagepub.com
Purpose Increased vascular access flow after percutaneous transluminal angioplasty (PTA)
for central venous stenosis and occlusion (central venous disease, CVD) can affect cardiac …