Clinical review of the Japanese experience with boron neutron capture therapy and a proposed strategy using epithermal neutron beams

Y Nakagawa, K Pooh, T Kobayashi, T Kageji… - Journal of neuro …, 2003 - Springer
Our concept of boron neutron capture therapy (BNCT) is selective destruction of tumor cells
using the heavy-charged particles yielded through 10 B(n, α) 7 Li reactions. To design a new …

Akt2 and Akt3 play a pivotal role in malignant gliomas

…, Y Mizobuchi, K Kuwayama, T Kageji… - Neuro …, 2009 - academic.oup.com
Akt, one of the major downstream effectors of phosphatidylinositol 3-kinase, is hyper-expressed
and activated in a variety of cancers including glioblastoma. However, the expression …

Boron neutron capture therapy for newly diagnosed glioblastoma

T Yamamoto, K Nakai, T Kageji, H Kumada… - Radiotherapy and …, 2009 - Elsevier
PURPOSE: The efficacy, safety, and dose distribution of neutron capture therapy (NCT) were
evaluated in 15 patients with newly diagnosed glioblastoma. METHODS AND MATERIALS: …

REIC/Dkk-3 induces cell death in human malignant glioma

…, K Kuwayama, K Kitazato, H Mure, T Kageji… - Neuro …, 2008 - academic.oup.com
The progression of glioma to more malignant phenotypes results from the stepwise
accumulation of genetic alterations and the consequent disruption of the apoptotic pathway and …

Reduction of endothelial tight junction proteins is related to cerebral aneurysm formation in rats

…, N Nakajima, J Satomi, T Kageji… - Journal of …, 2010 - journals.lww.com
Objective The formation of cerebral aneurysms is associated with endothelial damage and
macrophage migration. Hypothesizing that the opening of tight junctions due to the …

Boron neutron capture therapy (BNCT) for newly-diagnosed glioblastoma: comparison of clinical results obtained with BNCT and conventional treatment

T Kageji, S Nagahiro, Y Mizobuchi… - The Journal of Medical …, 2014 - jstage.jst.go.jp
The purpose of this study was to evaluate the clinical outcome of boron neutron capture
therapy (BNCT) and conventional treatment in patients with newly diagnosed glioblastoma. …

[HTML][HTML] Diagnosis of brain tumors using dynamic contrast-enhanced perfusion imaging with a short acquisition time

…, Y Obama, M Majigsuren, D Khashbat, T Kageji… - Springerplus, 2015 - Springer
This study sought to determine the diagnostic utility of perfusion parameters derived from
dynamic contrast-enhanced (DCE) perfusion MRI with a short acquisition time (approximately …

Clinicopathological characterization of TSH-producing adenomas: special reference to TSH-immunoreactive but clinically non-functioning adenomas

…, S Yamada, MM Rahman, N Inosita, T Kageji… - Endocrine …, 2009 - Springer
Thyrotropin (thyroid-stimulating hormone (TSH))-producing pituitary adenomas have been
known to be quite variable in clinical features covering from typical functioning TSH-…

Pharmacokinetics and boron uptake of BSH (Na2B12H11SH) in patients with intracranial tumors

T Kageji, Y Nakagawa, K Kitamura, K Matsumoto… - Journal of neuro …, 1997 - Springer
We evaluated retrospectively the pharmacokinetics and boron uptakeof BSH (mercaptoundecahydrododecarborate)
for Boron Neutron Capture Therapy(BNCT) in 123 patients …

Primary anaplastic pleomorphic xanthoastrocytoma with widespread neuroaxis dissemination at diagnosis––a pediatric case report and review of the literature

T Okazaki, T Kageji, K Matsuzaki, H Horiguchi… - Journal of neuro …, 2009 - Springer
We report a 5 year-old boy with primary anaplastic pleomorphic xanthoastrocytoma (PXA)
with whole neuroaxis dissemination at diagnosis who experienced the sudden onset of …