Druggable oncogene fusions in invasive mucinous lung adenocarcinoma

…, K Yasuda, M Hiramoto, T Nammo, T Ishigame… - Clinical cancer …, 2014 - AACR
Purpose: To identify druggable oncogenic fusions in invasive mucinous adenocarcinoma (IMA)
of the lung, a malignant type of lung adenocarcinoma in which KRAS mutations …

miRNA-148a-3p regulates immunosuppression in DNA mismatch repair–deficient colorectal cancer by targeting PD-L1

M Ashizawa, H Okayama, T Ishigame… - Molecular Cancer …, 2019 - AACR
This study provides novel evidence that miR-148a-3p negatively regulates tumor cell PD-L1
expression and decreased levels of miR-148a-3p contributes to the immunosuppressive …

The expression of four genes as a prognostic classifier for stage I lung adenocarcinoma in 12 independent cohorts

H Okayama, AJ Schetter, T Ishigame, AI Robles… - … Biomarkers & Prevention, 2014 - AACR
Background: We previously developed a prognostic classifier using the expression levels of
BRCA1, HIF1A, DLC1, and XPO1 that identified stage I lung adenocarcinoma patients with a …

A mouse model of KIF5B-RET fusion-dependent lung tumorigenesis

M Saito, T Ishigame, K Tsuta, K Kumamoto… - …, 2014 - academic.oup.com
Oncogenic fusion of the RET (rearranged during transfection) gene was recently identified
as a novel driver gene aberration not only for the development of thyroid carcinoma but also …

[HTML][HTML] Annexin A1 is involved in resistance to 5-FU in colon cancer cells

…, S Hayase, W Sakamoto, T Ishigame… - Oncology …, 2017 - spandidos-publications.com
Resistance to 5-fluorouracil (5‑FU), a key drug in the treatment of colorectal cancer, is one
of the major reasons for poor patient prognosis during cancer treatment. Annexin A1 (ANXA1) …

Laparoscopic surgery for acute diffuse peritonitis due to gastrointestinal perforation: A nationwide epidemiologic study using the national clinical database

…, H Kumamaru, H Hasegawa, T Ishigame… - Annals of …, 2022 - Wiley Online Library
Background Elective laparoscopic surgery is now widely accepted in the treatment of
abdominal diseases because of its minimal invasiveness and rapid postoperative recovery. It is …

Pancreatic metastasis of papillary thyroid carcinoma preoperatively diagnosed by endoscopic ultrasound-guided fine-needle aspiration biopsy: a case report with …

…, T Shimura, R Okada, Y Kofunato, T Ishigame… - Clinical Journal of …, 2018 - Springer
Pancreatic metastatic tumors from thyroid carcinoma are extremely rare. We report a case of
an 80-year-old female with a pancreatic metastatic tumor derived from papillary thyroid …

[HTML][HTML] Enhanced expression of KIF4A in colorectal cancer is associated with lymph node metastasis

…, S Hayase, W Sakamoto, T Ishigame… - Oncology …, 2018 - spandidos-publications.com
Kinesin family member 4A (KIF4A) is a member of the kinesin 4 subfamily of kinesin‑related
proteins and serves an important role in cell division. The expression levels of KIF4A have …

Predicting post-hepatectomy liver failure using intra-operative measurement of indocyanine green clearance in anatomical hepatectomy

…, S Suzushino, T Kimura, R Okada, T Ishigame… - World Journal of …, 2021 - Springer
Background Prediction of post-hepatectomy liver failure (PHLF) based on remnant liver function
reserve is important for successful hepatectomy. The aim of this study was to investigate …

Tissue-Engineered Hepatocyte Sheets Supplemented with Adipose-Derived Stem Cells

S Suzushino, N Sato, T Ishigame, R Okada… - … Engineering Part A, 2023 - liebertpub.com
The ability to engineer biologically viable hepatocytes and tissue matrices with long-term
functional maintenance has attracted considerable interest in the fields of hepatocyte …