Regulators of apoptosis are thought to work in concert, but the molecular interactions of this
process are not understood. Here, we show that in response to cell death stimulation, …

Inhibitor of apoptosis proteins (IAPs) regulate apoptosis primarily by inhibiting caspase-family
proteases. However, many IAPs also possess E3 ligase (ubiquitin-protein isopeptide ligase…

Integrity of the blood vessel wall is essential for vascular homeostasis and organ function 1 ,
2 . A dynamic balance between endothelial cell survival and apoptosis contributes to this …

Although the functions of chemokines in the regulation of immune processes have been
studied in some detail, the role of these biomolecules in cancer is not fully understood. …

In response to DNA damage and genotoxic stress, the p53 tumor suppressor triggers either
cell cycle arrest or apoptosis. The G 2 arrest after damage is, in part, mediated by the p53 …

The epithelial-to-mesenchymal transition (EMT) has received significant interest as a novel
target in cancer prevention, metastasis, and resistance. The conversion of cells from an …

We explored the location and function of the human cIAP1 protein, a member of the inhibitor
of apoptosis protein (IAP) family. Unlike family member X-linked IAP (XIAP), which was …

Biobased calcium carbonate and silver hybrid nanoparticles were synthesized using a simple
mechanochemical milling technique. The XRD spectrum showed that the hybrid materials …

Oral drug delivery systems provide the most convenient, noninvasive, readily acceptable
alternatives to parenteral systems. In the current work, eggshell-derived calcium carbonate (…

Although the prognostic value of p53 abnormalities in Stage III microsatellite stable (MSS)
colorectal cancers (CRCs) is known, the gene expression profiles specific to the p53 status in …