We recently identified a novel gene, termed klotho (kl) that is involved in the development of
a syndrome in mice resembling human aging. A defect of the kl gene expression in mice …

Background Screening and prophylactic treatment for hepatitis B virus (HBV) reactivation is
recommended for patients who receive immunosuppressive or cytotoxic therapy. The aim of …

Background: Cardiovascular disease is the leading cause of death in patients with end-stage
renal disease (ESRD). Previous studies showed that patients with ESRD had increased …

Although liposome-encapsulated clodronate has been used as a means to deplete macrophages
from certain tissues, target leukocyte subtypes within the kidney are not clearly known …

Background: Cerebrovascular diseases are very common in hemodialysis (HD) patients.
Silent cerebral infarction (SCI) has not been investigated in HD patients although it may be a …

5-Aminolevulinate synthase (ALAS) is a mitochondrial enzyme that catalyzes the first step of
the heme biosynthetic pathway. The mitochondrial import, as well as the synthesis, of the …

BACKGROUND Recent studies have demonstrated that peroxisome proliferator activator‐receptors
(PPAR)‐γ is expressed in some cancer cells such as breast, lung, and gastric cancer…

Intravesical inoculation of Mycobacterium bovis bacillus Calmette‐Guérin (BCG) has been
used for the treatment of bladder cancer. Recent studies implied the requirement of neutrophil …

We have cloned a cDNA coding for a novel steroid receptor co-activator protein termed
SRAP from a rat prostate library. Although the nucleotide sequence of the SRAP has 78.2% …

Immunotherapy based on blockade of the programmed death‐1 ( PD ‐1)/programmed death‐ligand
1 ( PD ‐L1) axis has shown promising clinical activity for renal cell carcinoma ( RCC …