… Lo, Long-Bin Jeng, Christina Wu, Tao-Wei KE have no any affiliation with or financial interest
in a … Tao-Wei Ke … William Tzu-Liang Chen and Tao-Wei Ke contributed equally to this work. …

Background MicroRNAs regulate gene expression at the posttranscriptional level and play
important roles in tumor development, progression, and metastasis. The aim of this study was …

Objectives The appendix may modulate colon microbiota and bowel inflammation. We
investigated whether appendectomy alters colorectal cancer risk. Methods We identified a cohort …

Dysfunctional mitochondria have been shown to enhance cancer cell proliferation, reduce
apoptosis, and increase chemoresistance. Chemoresistance develops in nearly all patients …

TGFβ contributes to chemoresistance in advanced colorectal cancer (CRC) via diverse
immune-microenvironment mechanisms. Here, we found that cancer cell autonomous TGFβ …

Programmed cell death-1 (PD-1) has demonstrated impressive clinical outcomes in several
malignancies, but its therapeutic efficacy in the majority of colorectal cancers is still low. …

Rectal cancer, which comprises 30% of all colorectal cancer cases, is one of the most
common forms of cancer in the world. Patients with locally advanced rectal cancer (LARC) are …

Programmed cell death-1 (PDCD1/PD-1) and its ligand programmed cell death 1 ligand 1 (CD274/PD-L1)
have been reported to suppress anti-tumor T cell-mediated immune responses…

This experiment explored the effects of single application of seven types of slow- and
controlled-release fertilizers on rice yield and various population characteristics. Based on a study …

The CD39-CD73–adenosinergic pathway converts adenosine triphosphate (ATP) to adenosine
for inhibiting anti-tumor immune responses. Therefore, targeting CD73 to reinvigorate …