Cytokines produced in the tumour microenvironment have an important role in cancer
pathogenesis. Altered cytokine expression may result in increased susceptibility to and/or poor …

Background and objectives: This study aimed to evaluate prognostic factors for post-recurrence
survival in local and locally advanced colorectal cancer patients. Materials and Methods: …

Background: The discovery that genetic alterations in oncogenes and tumour suppressor
genes accompany tumour formation in many human tumours has encouraged the search for …

Pathophysiological processes associated with disturbances in cell and tissue oxidative
homeostasis, are associated with self-catalyzed process of lipid peroxidation. The end products …

Although previously considered rare, recent epidemiological studies have revealed that the
incidence (3.6/100,000) and prevalence (35/100,000) of gastroenteropancreatic …

Microsatellite instability (MSI) represents an accumulation of frameshifts in short tandem
repeats, microsatellites, across the genome due to defective DNA mismatch repair (dMMR). MSI …

Nonsteroidal anti-inflammatory drugs (NSAIDs) lower the incidence of and mortality from
colon cancer. Although there is much evidence from epidemiological and laboratory studies …

Proinflammatory counterworks are important at different stages of tumor development,
particularly during invasion and metastasis. Immune cells and their signal molecules can …

Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are highly vascularized
neoplasms, capable of synthethisizing VEGF-A, a key mediator of angiogenesis. In pancreatic …

Vascular endothelial growth factor (VEGF) is important mediator of angiogenesis, and its
expression in colorectal tumors is related to tumor progression. VEGF expression has been …