Role of cytosolic phospholipase A2 in allergic response and parturition
Phospholipase A 2 (PLA 2 ) comprises a superfamily of enzymes that hydrolyse the ester
bond of phospholipids at the sn-2 position 1 , 2 , 3 . Among the members of this superfamily, …
bond of phospholipids at the sn-2 position 1 , 2 , 3 . Among the members of this superfamily, …
Effects of obstructive sleep apnea on circulating ICAM-1, IL-8, and MCP-1
…, H Wada, H Yamamoto, T Nagase… - Journal of applied …, 2003 - journals.physiology.org
Obstructive sleep apnea syndrome (OSAS) is one of the most important risk factors of
cardiovascular disorders. In the treatment of OSAS, nasal continuous positive airway pressure (…
cardiovascular disorders. In the treatment of OSAS, nasal continuous positive airway pressure (…
[HTML][HTML] TGF-β signaling in lung health and disease
A Saito, M Horie, T Nagase - International journal of molecular sciences, 2018 - mdpi.com
Transforming growth factor (TGF)-β is an evolutionarily conserved pleiotropic factor that
regulates a myriad of biological processes including development, tissue regeneration, immune …
regulates a myriad of biological processes including development, tissue regeneration, immune …
Acute lung injury by sepsis and acid aspiration: a key role for cytosolic phospholipase A2
Adult respiratory distress syndrome (ARDS) is characterized by acute lung injury with a high
mortality rate and yet its mechanism is poorly understood. Sepsis syndrome and acid …
mortality rate and yet its mechanism is poorly understood. Sepsis syndrome and acid …
Increased levels of circulating ICAM-1, VCAM-1, and L-selectin in obstructive sleep apnea syndrome
E Ohga, T Nagase, T Tomita… - Journal of Applied …, 1999 - journals.physiology.org
Obstructive sleep apnea syndrome (OSAS) may be one of the most important risk factors of
cardiovascular disorders, although the exact mechanism remains to be elucidated. In the …
cardiovascular disorders, although the exact mechanism remains to be elucidated. In the …
Identification of multiple novel epididymis-specific β-defensin isoforms in humans and mice
Y Yamaguchi, T Nagase, R Makita… - The Journal of …, 2002 - journals.aai.org
Defensins comprise a family of cationic antimicrobial peptides that are characterized by the
presence of six conserved cysteine residues. We identified two novel human β-defensin (hBD…
presence of six conserved cysteine residues. We identified two novel human β-defensin (hBD…
Multiple renal cysts, urinary concentration defects, and pulmonary emphysematous changes in mice lacking TAZ
…, T Takeuchi, A Mitani, T Nagase… - American Journal …, 2008 - journals.physiology.org
TAZ (transcriptional coactivator with PDZ-binding motif), also called WWTR1 (WW domain
containing transcription regulator 1), is a 14-3-3-binding molecule homologous to Yes-…
containing transcription regulator 1), is a 14-3-3-binding molecule homologous to Yes-…
Impaired anaphylactic responses with intact sensitivity to endotoxin in mice lacking a platelet-activating factor receptor
S Ishii, T Kuwaki, T Nagase, K Maki, F Tashiro… - The Journal of …, 1998 - rupress.org
Platelet-activating factor (PAF) is a potent phospholipid mediator with diverse biological
activities in addition to its well-known ability to stimulate platelet aggregation. Pharmacologic …
activities in addition to its well-known ability to stimulate platelet aggregation. Pharmacologic …
Localization of secretory mucins MUC5AC and MUC5B in normal/healthy human airways
…, SH Randell, H Matsui, T Nagase… - American journal of …, 2019 - atsjournals.org
Rationale: MUC5AC and MUC5B are the predominant gel-forming mucins in the mucus layer
of human airways. Each mucin has distinct functions and site-specific expression. However…
of human airways. Each mucin has distinct functions and site-specific expression. However…
[HTML][HTML] YAP/TAZ signaling as a molecular link between fibrosis and cancer
S Noguchi, A Saito, T Nagase - International journal of molecular sciences, 2018 - mdpi.com
Tissue fibrosis is a pathological condition that is associated with impaired epithelial repair
and excessive deposition of extracellular matrix (ECM). Fibrotic lesions increase the risk of …
and excessive deposition of extracellular matrix (ECM). Fibrotic lesions increase the risk of …