Role of cytosolic phospholipase A2 in allergic response and parturition

N Uozumi, K Kume, T Nagase, N Nakatani, S Ishii… - Nature, 1997 - nature.com
Phospholipase A 2 (PLA 2 ) comprises a superfamily of enzymes that hydrolyse the ester
bond of phospholipids at the sn-2 position 1 , 2 , 3 . Among the members of this superfamily, …

Effects of obstructive sleep apnea on circulating ICAM-1, IL-8, and MCP-1

…, H Wada, H Yamamoto, T Nagase… - Journal of applied …, 2003 - journals.physiology.org
Obstructive sleep apnea syndrome (OSAS) is one of the most important risk factors of
cardiovascular disorders. In the treatment of OSAS, nasal continuous positive airway pressure (…

[HTML][HTML] TGF-β signaling in lung health and disease

A Saito, M Horie, T Nagase - International journal of molecular sciences, 2018 - mdpi.com
Transforming growth factor (TGF)-β is an evolutionarily conserved pleiotropic factor that
regulates a myriad of biological processes including development, tissue regeneration, immune …

Acute lung injury by sepsis and acid aspiration: a key role for cytosolic phospholipase A2

T Nagase, N Uozumi, S Ishii, K Kume, T Izumi… - Nature …, 2000 - nature.com
Adult respiratory distress syndrome (ARDS) is characterized by acute lung injury with a high
mortality rate and yet its mechanism is poorly understood. Sepsis syndrome and acid …

Increased levels of circulating ICAM-1, VCAM-1, and L-selectin in obstructive sleep apnea syndrome

E Ohga, T Nagase, T Tomita… - Journal of Applied …, 1999 - journals.physiology.org
Obstructive sleep apnea syndrome (OSAS) may be one of the most important risk factors of
cardiovascular disorders, although the exact mechanism remains to be elucidated. In the …

Identification of multiple novel epididymis-specific β-defensin isoforms in humans and mice

Y Yamaguchi, T Nagase, R Makita… - The Journal of …, 2002 - journals.aai.org
Defensins comprise a family of cationic antimicrobial peptides that are characterized by the
presence of six conserved cysteine residues. We identified two novel human β-defensin (hBD…

Multiple renal cysts, urinary concentration defects, and pulmonary emphysematous changes in mice lacking TAZ

…, T Takeuchi, A Mitani, T Nagase… - American Journal …, 2008 - journals.physiology.org
TAZ (transcriptional coactivator with PDZ-binding motif), also called WWTR1 (WW domain
containing transcription regulator 1), is a 14-3-3-binding molecule homologous to Yes-…

Impaired anaphylactic responses with intact sensitivity to endotoxin in mice lacking a platelet-activating factor receptor

S Ishii, T Kuwaki, T Nagase, K Maki, F Tashiro… - The Journal of …, 1998 - rupress.org
Platelet-activating factor (PAF) is a potent phospholipid mediator with diverse biological
activities in addition to its well-known ability to stimulate platelet aggregation. Pharmacologic …

Localization of secretory mucins MUC5AC and MUC5B in normal/healthy human airways

…, SH Randell, H Matsui, T Nagase… - American journal of …, 2019 - atsjournals.org
Rationale: MUC5AC and MUC5B are the predominant gel-forming mucins in the mucus layer
of human airways. Each mucin has distinct functions and site-specific expression. However…

[HTML][HTML] YAP/TAZ signaling as a molecular link between fibrosis and cancer

S Noguchi, A Saito, T Nagase - International journal of molecular sciences, 2018 - mdpi.com
Tissue fibrosis is a pathological condition that is associated with impaired epithelial repair
and excessive deposition of extracellular matrix (ECM). Fibrotic lesions increase the risk of …