[HTML][HTML] Non-cell-autonomous cancer progression from chromosomal instability

…, E Lettera, M Deyell, B Tavora, JJ Havel, SM Phyu… - Nature, 2023 - nature.com
Chromosomal instability (CIN) is a driver of cancer metastasis 1 , 2 , 3 – 4 , yet the extent to
which this effect depends on the immune system remains unknown. Using ContactTracing—a …

[HTML][HTML] The clinical and molecular significance associated with STING signaling in breast cancer

…, E Gilmore, FA Sidi, V Bingham, SM Phyu… - NPJ Breast …, 2021 - nature.com
STING signaling in cancer is a crucial component of response to immunotherapy and other
anti-cancer treatments. Currently, there is no robust method of measuring STING activation in …

Effects of administered cardioprotective drugs on treatment response of breast cancer cells

TAD Smith, SM Phyu, EU Akabuogu - Anticancer Research, 2016 - ar.iiarjournals.org
Background: Anticancer drug treatment, particularly with anthracyclines, is frequently
associated with cardiotoxicity, an effect exacerbated by trastuzumab. Several compounds are in …

[HTML][HTML] Metformin decouples phospholipid metabolism in breast cancer cells

TAD Smith, SM Phyu - PLoS One, 2016 - journals.plos.org
Introduction The antidiabetic drug metformin, currently undergoing trials for cancer treatment,
modulates lipid and glucose metabolism both crucial in phospholipid synthesis. Here the …

[HTML][HTML] Probing the PI3K/Akt/mTor pathway using 31P-NMR spectroscopy: routes to glycogen synthase kinase 3

SM Phyu, CC Tseng, IN Fleming, TAD Smith - Scientific Reports, 2016 - nature.com
Akt is an intracellular signalling pathway that serves as an essential link between cell surface
receptors and cellular processes including proliferation, development and survival. The …

Changes in [18F]Fluoro-2-deoxy-d-glucose incorporation induced by doxorubicin and anti-HER antibodies by breast cancer cells modulated by co-treatment with …

AC Cooper, IN Fleming, SM Phyu… - Journal of cancer research …, 2015 - Springer
Purposes Metformin, currently undergoing clinical trials as an adjuvant for the treatment of
breast cancer, modulates the activity of key intracellular signalling molecules which affect 2-[ …

[HTML][HTML] Response detection of castrate-resistant prostate cancer to clinically utilised and novel treatments by monitoring phospholipid metabolism

TAD Smith, SM Phyu, KS Alzyoud… - BioMed Research …, 2017 - hindawi.com
Androgen receptor (AR) activation is the primary driving factor in prostate cancer which is
initially responsive to castration but then becomes resistant (castration-resistant prostate …

[PDF][PDF] Survey of classification techniques in data mining

TN Phyu - Proceedings of the international multiconference of …, 2009 - iaeng.org
Classification is a data mining (machine learning) technique used to predict group membership
for data instances. In this paper, we present the basic classification techniques. Several …

Ultra low-power full-adder for biomedical applications

ES Chew, MW Phyu, WL Goh - 2009 IEEE International …, 2009 - ieeexplore.ieee.org
… in Module I and are passed on to Module II and Module III for the generation of the Sum
and Cout outputs. The Sum and Cout outputs are formed using the following expressions [2]: …

[HTML][HTML] Combination treatment of cancer cells with pan-Akt and pan-mTOR inhibitors: effects on cell cycle distribution, p-Akt expression level and radiolabelled …

SM Phyu, TAD Smith - Investigational new drugs, 2019 - Springer
… The remaining cells were centrifuged and washed with 1 ml of PBS and the pellet dissolved
in 0.1 ml of NaOH (1 M) overnight for determination of protein concentration … Su Myat Phyu