[HTML][HTML] Tipifarnib in head and neck squamous cell carcinoma with HRAS mutations

…, L Licitra, I Nixon, NF Saba, S Hackenberg… - Journal of Clinical …, 2021 - ncbi.nlm.nih.gov
PURPOSE Mutations in the HRAS (mHRAS) proto-oncogene occur in 4%-8% of patients
with recurrent and/or metastatic (R/M) head and neck squamous cell carcinoma (HNSCC). …

Intracellular distribution, geno-and cytotoxic effects of nanosized titanium dioxide particles in the anatase crystal phase on human nasal mucosa cells

S Hackenberg, G Friehs, K Froelich, C Ginzkey… - Toxicology letters, 2010 - Elsevier
Nanomaterials are defined as substances with at least one dimension smaller than 100nm
in size and are used for a multitude of purposes. Titanium dioxide nanoparticles (TiO 2 -NPs) …

Repetitive exposure to zinc oxide nanoparticles induces DNA damage in human nasal mucosa mini organ cultures

S Hackenberg, FZ Zimmermann… - Environmental and …, 2011 - Wiley Online Library
Data on the toxicological properties of zinc oxide nanoparticles (ZnO‐NPs) is incomplete.
ZnO‐NPs may enter humans via inhalation or ingestion. The aim of the current study was to …

Silver nanoparticles: evaluation of DNA damage, toxicity and functional impairment in human mesenchymal stem cells

S Hackenberg, A Scherzed, M Kessler, S Hummel… - Toxicology letters, 2011 - Elsevier
Silver nanoparticles (Ag-NPs) are the most frequent commercialized nanomaterial currently.
Due to a distinct lack of information on hazardous properties of Ag-NPs in human cells, a …

Cytotoxic, genotoxic and pro-inflammatory effects of zinc oxide nanoparticles in human nasal mucosa cells in vitro

S Hackenberg, A Scherzed, A Technau, M Kessler… - Toxicology in vitro, 2011 - Elsevier
Despite increasing application of zinc oxide nanoparticles (ZnO-NPs) for industrial porpuses,
data about potential toxic properties is contradictory. The current study focused on the cyto- …

[HTML][HTML] Molecular mechanisms of zinc oxide nanoparticle-induced genotoxicity

A Scherzad, T Meyer, N Kleinsasser, S Hackenberg - Materials, 2017 - mdpi.com
Background: Zinc oxide nanoparticles (ZnO NPs) are among the most frequently applied
nanomaterials in consumer products. Evidence exists regarding the cytotoxic effects of ZnO …

[HTML][HTML] Antitumor activity of photo-stimulated zinc oxide nanoparticles combined with paclitaxel or cisplatin in HNSCC cell lines

S Hackenberg, A Scherzed, W Harnisch… - … of Photochemistry and …, 2012 - Elsevier
Zinc oxide nanoparticles (ZnO-NPs) exhibit photocatalytic properties and are used in
sunscreen cosmetics and for the degradation of environmental pollutants. Furthermore, ZnO-NPs …

Zinc oxide nanoparticles induce photocatalytic cell death in human head and neck squamous cell carcinoma cell lines in vitro

S Hackenberg, A Scherzed… - International …, 2010 - spandidos-publications.com
The aim of this study was to determine the photocatalytic effects of zinc oxide (ZnO) NPs in
combination with UVA-1 in human head and neck squamous cell carcinoma (HNSCC) cell …

[HTML][HTML] Time-dependent toxic and genotoxic effects of zinc oxide nanoparticles after long-term and repetitive exposure to human mesenchymal stem cells

…, K Radeloff, N Kleinsasser, S Hackenberg - International journal of …, 2017 - mdpi.com
Zinc oxide nanoparticles (ZnO-NP) are widely spread in consumer products. Data about the
toxicological characteristics of ZnO-NP is still under controversial discussion. The human …

Nanosized titanium dioxide particles do not induce DNA damage in human peripheral blood lymphocytes

S Hackenberg, G Friehs, M Kessler… - Environmental and …, 2011 - Wiley Online Library
Industrial application of titanium dioxide nanoparticles (TiO 2 ‐NPs) as an additive in
pharmaceutical and cosmetic products is increasing. However, the knowledge about the toxicity of …