A new series of betulin derivatives containing one or two pharmacophores bearing an
acetylenic and carbonyl function at the C-3 and/or C-28 positions has been synthesized and …

Background A large body of research has focused on fluoroquinolones. It was shown that
this class of synthetic antibiotics could possess antiviral activity as a broad range of anti-…

A key parameter in the design of new active compounds is lipophilicity, which influences the
solubility and permeability through membranes. Lipophilicity affects the pharmacodynamic …

Betulin derivatives containing a 1,2,3-triazole ring possess a wide spectrum of biological
activities, including antiviral, anticancer, and antibacterial activity. A series of novel triazoles …

The CuAAC reaction of azides and acetylenic triterpenes was used for synthesis of new
triazoles of 3-acetylbetulin and betulone. The triazole derivatives were evaluated for their …

Betulin-1,4-quinone hybrids were obtain by connecting two active structures with a linker.
This strategy allows for obtaining compounds showing a high biological activity and better …

Betulin 1 and its semisynthetic derivatives exhibit a cytotoxic activity toward various cancer
cell lines. These compounds are a promising and potential anticancer candidates. A series of …

A series of 30-diethylphosphate derivatives of betulin were synthesized and evaluated for
their in vitro cytotoxic activity against human cancer cell lines, such as amelanotic melanoma (…

Betulin is a lupane triterpenoid [lup-20(29)-ene-3β,28-diol, C 30 H 50 O 2 ] showing high
biological activity. This activity is supposed to be strongly affected by the molecular structure of …

Betulin derivatives exhibit an antiproliferative activity and have been tested for many cancer
cell lines. This paper describes a new series of 3-phosphate derivatives of betulin bearing …