Natural products that target cancer stem cells

J Moselhy, S Srinivasan, MK Ankem… - Anticancer …, 2015 - ar.iiarjournals.org
The cancer stem cell model suggests that tumor initiation is governed by a small subset of
distinct cells with stem-like character termed cancer stem cells (CSCs). CSCs possess …

Notch-1 inhibition by Withaferin-A: a therapeutic target against colon carcinogenesis

S Koduru, R Kumar, S Srinivasan, MB Evers… - Molecular cancer …, 2010 - AACR
Notch signaling plays a crucial role in the development of colon cancer; targeting the Notch
pathway may sensitize colon cancers to various adjuvant agents. The focus of our current …

Par-4-dependent apoptosis by the dietary compound withaferin A in prostate cancer cells

S Srinivasan, RS Ranga, R Burikhanov, SS Han… - Cancer research, 2007 - AACR
Deletion or mutation of the androgen receptor (AR) renders prostate tumors refractory to
apoptosis by androgen ablation, the mainstay of prostate cancer therapy. To identify novel …

Diosgenin targets Akt‐mediated prosurvival signaling in human breast cancer cells

S Srinivasan, S Koduru, R Kumar… - … Journal of Cancer, 2009 - Wiley Online Library
In recent years, Akt signaling has gained recognition for its functional role in more aggressive,
therapy‐resistant malignancies. As it is frequently constitutively active in cancer cells, …

Anticancer mechanism of plumbagin, a natural compound, on non-small cell lung cancer cells

R Gomathinayagam, S Sowmyalakshmi… - Anticancer …, 2008 - ar.iiarjournals.org
Background: Lung cancer is the leading cause of cancer-related deaths in the United States.
Prevailing treatment options have limited therapeutic success in lung cancer, particularly …

Inhibiting TNF-mediated signaling: a novel therapeutic paradigm for androgen independent prostate cancer

S Srinivasan, R Kumar, S Koduru, A Chandramouli… - Apoptosis, 2010 - Springer
The tumor necrosis factor (TNF) receptor super family comprises of members that induce two
distinct signaling cascades, leading to either cell survival or apoptosis. However, in prostate …

Landomycins P−W, Cytotoxic Angucyclines from Streptomyces cyanogenus S-136

KA Shaaban, S Srinivasan, R Kumar… - Journal of natural …, 2011 - ACS Publications
Streptomyces cyanogenus S-136 is the producer of previously reported landomycins A−D.
An analysis of minor products of the strain led to isolation and structure elucidation of eight …

Investigation on Semecarpus Lehyam—a Siddha medicine for breast cancer

S Sowmyalakshmi, M Nur-e-Alam, MA Akbarsha… - Planta, 2005 - Springer
The use of complementary and alternative medicines for breast cancer patients has been
increasing every year. Traditional Indian systems of medicine, such as Siddha, have been …

A herbal medicine for the treatment of lung cancer

RS Ranga, S Sowmyalakshmi, R Burikhanov… - Molecular and cellular …, 2005 - Springer
Lung cancer is the leading cause of cancer-related deaths throughout the world. Extracts of
medicinal plants are believed to contain different chemopreventive or chemotherapeutic …

Psoralidin, an Herbal Molecule, Inhibits Phosphatidylinositol 3-Kinase–Mediated Akt Signaling in Androgen-Independent Prostate Cancer Cells

R Kumar, S Srinivasan, S Koduru, P Pahari… - Cancer Prevention …, 2009 - AACR
The protein kinase Akt plays an important role in cell proliferation and survival in many cancers,
including prostate cancer. Due to its kinase activity, it serves as a molecular conduit for …