Phyllodes tumours constitute an uncommon but complex group of mammary fibroepithelial
lesions. Accurate and reproducible grading of these tumours has long been challenging, …

Optimal management of high-risk breast lesions detected by mammogram yielding atypical
ductal hyperplasia, flat epithelial atypia, atypical lobular hyperplasia, lobular carcinoma in situ…

Minimally invasive breast biopsy procedures performed for suspicious imaging findings
have expanded the role of breast imaging in the management of breast diseases. The first …

The GATA family members are zinc finger transcription factors involved in cell differentiation
and proliferation. GATA3 in particular is necessary for mammary gland maturation, and its …

The HER‐2/neu gene is a proto‐oncogene that is amplified in 10–30% of breast cancers.
New drugs for targeted therapy, such as Herceptin, are effective for patients with HER‐2/neu‐…

Core biopsies are commonly used in the diagnosis of breast cancer and often are the only
sample for providing prognostic and predictive markers prior to neoadjuvant chemotherapy. …

The pathobiology of precursor lesions leading to invasive pancreatic adenocarcinoma
remains a controversial area, but knowledge of the mechanisms of tumorigenesis may lead to …

BACKGROUND Limited studies have examined the impact of the Bethesda System for
Reporting Thyroid Cytopathology (BSRTC) and specifically the category of atypia or follicular …

Accurate determination of HER2/neu status in breast carcinoma is essential. Alteration of
preanalytic variables is known to affect HER2/neu results. American Society of Clinical …

In breast cancer, recent studies suggest that the value of HER2 for predicting response to
anthracycline-based chemotherapy may be more likely related to the concomitant amplification …