Introduction The aim of our analysis was to evaluate the prognostic effect of programmed
cell death ligand-1 (PD-L1) expression in patients with non–small cell lung cancer (NSCLC). …

The aim of this study was to determine the distribution of known oncogenic driver mutations
in female never-smoker Asian patients with lung adenocarcinoma. We analyzed 214 …

Loss of E-cadherin, a hallmark of epithelial-mesenchymal transition (EMT), can significantly
affect metastatic dissemination. However, the molecular mechanism of EMT-associated …

p18 was first identified as a factor associated with a macromolecular tRNA synthetase
complex. Here we describe the mouse p18 loss-of-function phenotype and a role for p18 in the …

Introduction: Anaplastic lymphoma kinase (ALK) fusion is the most common mechanism for
overexpression and activation in non–small-cell lung carcinoma. Several fusion partners of …

AIMP2/p38 is a scaffolding protein required for the assembly of the macromolecular tRNA
synthetase complex. Here, we describe a previously unknown function for AIMP2 as a positive …

An increasing number of chromosomal aberrations is being identified in solid tumors providing
novel biomarkers for various types of cancer and new insights into the mechanisms of …

The metastatic potential of non-small cell lung cancer (NSCLC) has been shown to be associated
with interactions with the tumor microenvironment, which primarily comprises of cancer…

Background Deep sequencing techniques provide a remarkable opportunity for comprehensive
understanding of tumorigenesis at the molecular level. As omics studies become popular…

Although lung cancers with activating mutations in the epidermal growth factor receptor (EGFR)
are highly sensitive to selective EGFR tyrosine kinase inhibitors (TKIs), these tumors …