Did you mean: SHUNICHI SHIOZAWA

Pathogenesis of rheumatoid arthritis and c-Fos/AP-1

S Shiozawa, K Tsumiyama - Cell Cycle, 2009 - Taylor & Francis
c-Fos/AP-1 controls the expression of inflammatory cytokines and matrix-degrading matrix
metalloproteinases (MMPs) important in arthritis via promoter AP-1 binding motif. Among …

Pathogenesis of joint destruction in rheumatoid arthritis

S Shiozawa, K Tsumiyama, K Yoshida… - Archivum immunologiae …, 2011 - Springer
Synovial mesenchymal cells, matrix metalloproteinases (MMPs), and osteoclasts are the
three major players directly responsible for the pathogenesis of rheumatoid joint destruction. …

Interferon‐alpha in lupus psychosis

S Shiozawa, Y Kuroki, M Kim… - … : Official Journal of the …, 1992 - Wiley Online Library
Objective. Since the level of interferon‐α (IFNα) is increased in the sera of patients with active
systemic lupus erythematosus (SLE) and is detectable in the cerebrospinal fluid (CSF) of …

Dual metabolic pathway of 25‐hydroxyvitamin D3 catalyzed by human CYP24

…, N Sawada, K Komai, S Shiozawa… - European journal of …, 2000 - Wiley Online Library
Human 25‐hydroxyvitamin D 3 (25(OH)D 3 ) 24‐hydroxylase (CYP24) cDNA was
expressed in Escherichia coli, and its enzymatic and spectral properties were revealed. The …

Mammalian clock gene Cryptochrome regulates arthritis via proinflammatory cytokine TNF-α

…, F Yamazaki, H Okamura, S Shiozawa - The journal of …, 2010 - journals.aai.org
The mammalian clock genes, Period and Cryptochrome (Cry), regulate circadian rhythm.
We show that circadian rhythmicity and rhythmic expression of Period in the nuclei of …

Treatment of arthritis with a selective inhibitor of c-Fos/activator protein-1

…, A Hashiramoto, H Narita, S Hirono, S Shiozawa - Nature …, 2008 - nature.com
To inhibit arthritis upstream of inflammatory cytokine release and matrix metalloproteinase (MMP)
action, we designed de novo a small-molecule inhibitor of c-Fos/activator protein-1 (AP…

Hypermethylated promoter region of DR3, the death receptor 3 gene, in rheumatoid arthritis synovial cells

…, K Shiozawa, A Hashiramoto, S Shiozawa - Arthritis & …, 2006 - Wiley Online Library
Objective To examine the promoter activity and protein expression of the death receptor 3
gene DR3, a member of the apoptosis‐inducing Fas gene family, with particular reference to …

Morphologic observations in the early phase of the cartilage‐pannus junction

S Shiozawa, K Shiozawa, T Fujita - Arthritis & Rheumatism …, 1983 - Wiley Online Library
The early phase of cartilage destruction by active cellular pannus in rheumatoid joints was
observed under light and electron microscopy. In the early phase of pannus formation, …

Identification of the gene loci that predispose to rheumatoid arthritis.

S Shiozawa, S Hayashi, Y Tsukamoto… - International …, 1998 - academic.oup.com
We have searched the human genome for genes that predispose to rheumatoid arthritis (RA)
using fluorescence-based microsatellite marker analysis and affected sib-pair linkage study…

Whole genome association study of rheumatoid arthritis using 27 039 microsatellites

…, T Minezaki, K Komai, S Shiozawa… - Human molecular …, 2005 - academic.oup.com
A major goal of current human genome-wide studies is to identify the genetic basis of
complex disorders. However, the availability of an unbiased, reliable, cost efficient and …
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