It has been shown that constitutively active Wnt5a-Ror2 signaling in osteosarcoma cell lines
plays crucial roles in induced expression of matrix metalloproteinase-13 (MMP-13), required …

In this study, we aimed to examine the clinical value of the pleural effusion (PE) biomarkers,
soluble mesothelin-related peptide (SMRP), cytokeratin 19 fragment (CYFRA 21–1) and …

Background/Aim: Previous reviews of Social determinants of health in lung cancer patients
have not examined essential factors such as social isolation and loneliness. This study aimed …

Purpose The purpose of this study was to investigate the impact of social isolation and
loneliness on the overall survival and death at home in patients with lung cancer. Methods This …

Background: Social determinants of health (SDHs) are social factors that affect human health;
loneliness and social isolation are core SDH factors. There is a possibility that SDHs are …

Parathyroid crisis, which might occur during the natural history of primary hyperparathyroidism,
presents fatal hypercalcemia. Although hyperparathyroidism is known to cause …

Objective To describe the clinical research support systems in Japanese board certification
programs of internal medicine and to assess the relationship between these support systems …

Metastatic pulmonary calcification (MPC) is calcium deposition in normal pulmonary parenchyma
due to abnormal calcium metabolism. We present a case report of rapid progression of …

Background Malignant pleural effusion reduces cancer patients’ quality of life. Some experts
have suggested that chest tubes should be directed posteriorly during pleurodesis. We …

… Shunkichi Ikegaki, Hirotaka Matsumoto, corresponding author Yuki Kataoka, Katsuya
Hirano, Hiraku Tsujimoto, Yukihiko Nakata, and Morihiro Katsura … The writing group for …