NF-κB and AP-1 connection: mechanism of NF-κB-dependent regulation of AP-1 activity

S Fujioka, J Niu, C Schmidt, GM Sclabas… - … and cellular biology, 2004 - Taylor & Francis
Nuclear factor κB (NF-κB) and activator protein 1 (AP-1) transcription factors regulate many
important biological and pathological processes. Activation of NF-κB is regulated by the …

Tokyo Guidelines 2018: surgical management of acute cholecystitis: safe steps in laparoscopic cholecystectomy for acute cholecystitis (with videos)

…, A Horiguchi, N Tagaya, S Fujioka… - Journal of Hepato …, 2018 - Wiley Online Library
In some cases, laparoscopic cholecystectomy (LC) may be difficult to perform in patients with
acute cholecystitis (AC) with severe inflammation and fibrosis. The Tokyo Guidelines 2018 (…

Function of nuclear factor κB in pancreatic cancer metastasis

S Fujioka, GM Sclabas, C Schmidt, WA Frederick… - Clinical cancer …, 2003 - AACR
Purpose: We seek to elucidate the role of constitutive nuclear factor κB (NFκB) activity in
human pancreatic cancer cells. We have demonstrated that the transcription factor NFκB is …

[PDF][PDF] Mechanisms of proinflammatory cytokine-induced biphasic NF-κB activation

C Schmidt, B Peng, Z Li, GM Sclabas, S Fujioka, J Niu… - Molecular cell, 2003 - cell.com
The transcription factor NF-κB regulates genes involved in innate and adaptive immune
response, inflammation, apoptosis, and oncogenesis. Proinflammatory cytokines induce the …

Overexpression of tropomysin-related kinase B in metastatic human pancreatic cancer cells

GM Sclabas, S Fujioka, C Schmidt, Z Li… - Clinical cancer …, 2005 - AACR
Purpose: Pancreatic adenocarcinoma is currently the fourth leading cause of cancer death
in the United States, and most pancreatic cancers develop locally advanced disease or …

Inhibition of constitutive NF-κB activity by IκBαM suppresses tumorigenesis

S Fujioka, GM Sclabas, C Schmidt, J Niu, WA Frederick… - Oncogene, 2003 - nature.com
We have demonstrated that nuclear factor-κB (NF-κB) is constitutively activated in human
pancreatic adenocarcinoma and human pancreatic cancer cell lines but not in normal …

The function of multiple IκB: NF-κB complexes in the resistance of cancer cells to Taxol-induced apoptosis

QG Dong, GM Sclabas, S Fujioka, C Schmidt, B Peng… - Oncogene, 2002 - nature.com
The Rel/NF-κB transcription factors play a key role in the regulation of apoptosis and in
tumorigenesis by controlling the expressions of specific genes. To determine the role of the …

[HTML][HTML] Stabilization of p53 is a novel mechanism for proapoptotic function of NF-κB

S Fujioka, C Schmidt, GM Sclabas, Z Li… - Journal of Biological …, 2004 - ASBMB
Both pro- and antiapoptotic activities of NF-κB transcription factor have been observed;
however, less is known about the mechanism by which NF-κB induces apoptosis. To elucidate …

Placement of a metallic stent across the main duodenal papilla may predispose to cholangitis

T Okamoto, S Fujioka, S Yanagisawa, K Yanaga… - Gastrointestinal …, 2006 - Elsevier
BACKGROUND: Cholangitis is a major complication after metallic stent placement to treat
biliary obstruction, and it may impair quality of life. Whether transpapillary stent placement …

Doxycycline induces apoptosis in PANC-1 pancreatic cancer cells

K Son, S Fujioka, T Iida, K Furukawa, T Fujita… - Anticancer …, 2009 - ar.iiarjournals.org
Background: Tetracyclines such as doxycycline are reported to possess cytotoxic activity
against mammalian tumor cells, but the mechanism of their effects on cell proliferation remains …