Background This study explored the prognostic impact of tumor-infiltrating lymphocytes (TILs)
and investigated whether three histologic subtypes (lymphoepithelioma-like carcinoma, …

Background Immune checkpoint inhibitors (ICIs) have been increasingly used in cancer
treatment, and a subset of patients undergo pseudoprogression. Recognizing the incidence of …

Background A diagnosis of cancer is associated with an increased suicide risk, and this risk
is the highest within the first year of diagnosis. The aim of the present study was to determine …

Immune-related adverse events (irAEs) induced by checkpoint inhibitors involve a multitude
of different risk factors. Here, to interrogate the multifaceted underlying mechanisms, we …

Importance Hyperprogressive disease (HPD) is a recognized pattern of rapid tumor progression
during immune checkpoint inhibitor (ICI) treatment. Definitions of HPD have not been …

Oncogenic EGFR is essential for the development and growth of non–small cell lung cancer
(NSCLC), but the precise roles of EGFR in lung cancer metabolism remain unclear. Here, …

Purpose Hereditary leiomyomatosis and renal cell carcinoma (HLRCC) is a rare genetic
syndrome resulting from germline mutations in fumarate hydratase. The combination of …

Introduction Recent lung adenocarcinoma (LUAD) grading system proposed by the International
Association for the Study of Lung Cancer (IASLC) has emphasized the proportion of …

Anti-PD-1/PD-L1 immunotherapy, as a treatment for many tumors, has shown good efficacy.
However, responses to immunotherapy did not always occur or last long., ie primary or …

Purpose To analyse the incidence of pneumonitis related to enfortumab vedotin (EV) in
patients with metastatic urothelial cell carcinoma (mUC). Methods Patients with mUC who …