Intercellular adhesion molecule-1–deficient mice are resistant against renal injury after induction of diabetes

S Okada, K Shikata, M Matsuda, D Ogawa, H Usui… - Diabetes, 2003 - Am Diabetes Assoc
Diabetic nephropathy is a leading cause of end-stage renal failure. Several mechanisms,
including activation of protein kinase C, advanced glycation end products, and overexpression …

Thiazolidinedione ameliorates renal injury in experimental diabetic rats through anti-inflammatory effects mediated by inhibition of NF-κB activation

S Ohga, K Shikata, K Yozai, S Okada… - American Journal …, 2007 - journals.physiology.org
Thiazolidinedione (TZD), a ligand for peroxisome proliferator-activated receptor-γ (PPAR-γ),
exerts anti-inflammatory effects independently of the insulin-sensitizing effect. In the present …

[HTML][HTML] A review of clinical characteristics and genetic backgrounds in Alport syndrome

…, K Nakanishi, Y Abe, T Udagawa, S Okada… - Clinical and …, 2019 - Springer
Alport syndrome (AS) is a progressive hereditary renal disease that is characterized by
sensorineural hearing loss and ocular abnormalities. It is divided into three modes of inheritance, …

[HTML][HTML] Fisetin lowers methylglyoxal dependent protein glycation and limits the complications of diabetes

P Maher, R Dargusch, JL Ehren, S Okada, K Sharma… - PLoS …, 2011 - journals.plos.org
The elevated glycation of macromolecules by the reactive dicarbonyl and α-oxoaldehyde
methylglyoxal (MG) has been associated with diabetes and its complications. We have …

HMG‐CoA reductase inhibitor ameliorates diabetic nephropathy by its pleiotropic effects in rats

H Usui, K Shikata, M Matsuda, S Okada… - Nephrology Dialysis …, 2003 - academic.oup.com
Background. An inflammatory process may be one of the critical factors that contribute to the
development of diabetic nephropathy (DN). We reported previously that intercellular …

Pirfenidone is renoprotective in diabetic kidney disease

…, TA McGowan, I Toh, SR Dunn, S Okada… - Journal of the …, 2009 - journals.lww.com
Although several interventions slow the progression of diabetic nephropathy, current therapies
do not halt progression completely. Recent preclinical studies suggested that pirfenidone …

Clinical features of non-diabetic renal diseases in patients with type 2 diabetes

A Tone, K Shikata, M Matsuda, H Usui, S Okada… - Diabetes research and …, 2005 - Elsevier
Although persistent proteinuria is characteristic of diabetic nephropathy (DN), it is important
to differentiate non-diabetic renal diseases (NDRD) in diabetic patients with proteinuria. In …

Obesity related kidney disease

AV Mathew, S Okada, K Sharma - Current diabetes reviews, 2011 - ingentaconnect.com
Obesity is a risk factor for both de novo disease and as a complication of existing chronic
kidney disease. Obesity related disease is characterized by albuminuria, glomerulomegaly and …

Role of Nox2 in diabetic kidney disease

YH You, S Okada, S Ly… - American Journal …, 2013 - journals.physiology.org
NADPH oxidase (Nox) isoforms have been implicated in contributing to diabetic microvascular
complications, but the functional role of individual isoforms in diabetic kidney are unclear. …

TRB3 is stimulated in diabetic kidneys, regulated by the ER stress marker CHOP, and is a suppressor of podocyte MCP-1

…, YH You, DP Pizzo, S Okada… - American Journal …, 2010 - journals.physiology.org
The prevalence of diabetic nephropathy continues to rise, highlighting the importance of
investigating and discovering novel treatment strategies. TRB3 is a kinase-like molecule that …