During transduction of an apoptotic (death) signal into the cell, there is an alteration in the
permeability of the membranes of the cell's mitochondria, which causes the translocation of the …

Programmed cell death can be divided into several categories including type I (apoptosis)
and type II (autophagic death) 1 , 2 . The Bcl-2 family of proteins are well-characterized …

Macroautophagy is a process that leads to the bulk degradation of subcellular constituents
by producing autophagosomes/autolysosomes 1 , 2 , 3 . It is believed that Atg5 (ref. 4 ) and …

As a stress response, senescence is a dynamic process involving multiple effector mechanisms
whose combination determines the phenotypic quality. Here we identify autophagy as a …

Macroautophagy is a highly conserved intracellular process responsible for the degradation
of subcellular constituents. Macroautophagy was recently suggested to be involved in the …

Mitochondria play an important role in energy production, Ca 2+ homeostasis and cell death.
In recent years, the role of the mitochondria in apoptotic and necrotic cell death has …

Although apoptosis and necrosis are morphologically distinct manifestations of cell death,
apoptosis and some necroses share common features in the death signaling pathway …

Cytochrome c release and the mitochondrial permeability transition (PT), including loss of
the transmembrane potential (Δψ), play an important role in apoptosis. Using isolated …

The Bcl-2 family of proteins that consists of anti-apoptotic and pro-apoptotic members
determines life-or-death of a cell by controlling the release of mitochondrial apoptogenic factors, …

THE proto-oncogene bcl-2, isolated from the t(14;18) chromosomal breakpoint in follicular B-lymphoma
1–3 , and abcl-2-related gene bcl-x (ref. 4) prevent apoptotic cell death induced …