X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

…, BS Chang, CB Thompson, SL Wong, SC Ng… - Nature, 1996 - nature.com
THE Bcl-2 family of proteins regulate programmed cell death by an unknown mechanism 1 .
Here we describe the crystal and solution structures of a Bcl-2 family member, Bcl-x L (ref. 2)…

NMR structure and mutagenesis of the inhibitor-of-apoptosis protein XIAP

…, H Wang, J Chen, H Zhang, W Wu, N Xu, SC Ng… - Nature, 1999 - nature.com
The inhibitor-of-apoptosis (IAP) family of proteins, originally identified in baculoviruses 1 ,
regulate programmed cell death in a variety of organisms 2 , 3 , 4 , 5 , 6 . IAPs inhibit specific …

Distinctive roles of PHAP proteins and prothymosin-α in a death regulatory pathway

…, Y Zhao, H Zhang, J Kofron, J Donnelly, D Burns, S Ng… - Science, 2003 - science.org
A small molecule, α-(trichloromethyl)-4-pyridineethanol (PETCM), was identified by high-throughput
screening as an activator of caspase-3 in extracts of a panel of cancer cells. PETCM …

Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL

…, WJ McClellan, M Mitten, SC Ng… - Journal of medicinal …, 2007 - ACS Publications
Overexpression of the antiapototic proteins Bcl-2 and Bcl-xL provides a common mechanism
through which cancer cells gain a survival advantage and become resistant to conventional …

Influence of Bcl-2 family members on the cellular response of small-cell lung cancer cell lines to ABT-737

…, AV Sarthy, J Chen, RB Warner, SC Ng… - Cancer research, 2007 - AACR
ABT-737 is a novel and potent Bcl-2 antagonist with single-agent activity against small-cell
lung cancer (SCLC) cell lines. Here, we evaluated the contribution of Bcl-2 family members to …

Down-regulation of survivin by antisense oligonucleotides increases apoptosis, inhibits cytokinesis and anchorage-independent growth

…, S Krajewski, M Krajewska, K Welsh, JC Reed, SC Ng - Neoplasia, 2000 - Elsevier
… Reedz and Shi-Chung Ng* … E-mail: shi - chung.c.ng@abbott.com yThe work in Reed's lab
was supported partially by NIH grant AG - 15402. 1These authors contributed equally to the …

NMR structure and mutagenesis of the FADD (Mort1) death-effector domain

M Eberstadt, B Huang, Z Chen, RP Meadows, SC Ng… - Nature, 1998 - nature.com
When activated, membrane-bound receptors for Fas and tumour-necrosis factor initiate
programmed cell death by recruiting the death domain of the adaptor protein FADD 1 (Mort1; 2 ) …

Expression of the potent vasoconstrictor endothelin in the human central nervous system.

ME Lee, SM De la Monte, SC Ng… - The Journal of …, 1990 - Am Soc Clin Investig
Endothelin is a potent vasoconstrictive peptide initially characterized as a product of
endothelial cells. To examine the potential role of endothelin as a neuropeptide, we studied its …

[PDF][PDF] Crystal structure and mutagenic analysis of the inhibitor-of-apoptosis protein survivin

…, D Zakula, ED Matayoshi, W Wu, H Zhang, F Li, SC Ng… - Molecular cell, 2000 - cell.com
The coupling of apoptosis (programmed cell death) to the cell division cycle is essential for
homeostasis and genomic integrity. Here, we report the crystal structure of survivin, an …

Discovery and structure− activity relationship of antagonists of B-cell lymphoma 2 family proteins with chemopotentiation activity in vitro and in vivo

…, H Zhang, PM Nimmer, SC Ng… - Journal of medicinal …, 2006 - ACS Publications
Development of a rationally designed potentiator of cancer chemotherapy, via inhibition of
Bcl-X L function, is described. Lead compounds generated by NMR screening and directed …