Quinine was first recognized as a potent antimalarial agent hundreds of years ago. Since
then, the beneficial effects of quinine and its more advanced synthetic forms, chloroquine and …

Autoimmunity can be triggered by many environmental factors, among which infectious agents
are pivotal. Here, we summarize current knowledge of the relationship between infection …

The role of vitamin D as an immune modulator has been emphasized in recent years, and
low levels of the hormone were observed in several autoimmune diseases including multiple …

The role of the proapototic Bax gene in ischemia-reperfusion (I/R) injury was studied in three
groups of mice: homozygotic knockout mice lacking the Bax gene (Bax −/− ), heterozygotic …

Neuropsychiatric symptoms affect nearly half of the patients with systemic lupus erythematosus;
however, the effect on disease severity, quality of life, and prognosis is tremendous. …

Studies are emerging alluding to the role of intestinal microbiome in the pathogenesis of
diseases. Intestinal microbiome is susceptible to the influence of environmental factors such as …

Objective Familial Mediterranean fever (FMF) is refractory to colchicine prophylaxis in 10–20%
of patients. In a number of patient series, treatment with anakinra, an interleukin‐1–…

Sjögren's syndrome (SS) is an autoimmune disease characterized primarily by lymphocytic
infiltration of the exocrine glands, and autoantibody production. Multiple environmental …

Background: Hypovitaminosis D has been shown to be extremely common in various
regions around the world, mostly at high latitudes. Israel is characterized by certain features–…

Studies in different populations with high risk for cardiovascular disease (CVD) have shown
an association between serum uric acid (SUA) and CVD. However, only a few studies have …