Uveal melanoma arises from melanocytes located in the uveal tract of the eye and is the most
common primary intraocular tumor in adults. Metastatic liver disease is the overwhelming …

Lysyl oxidase is a marker of poor prognosis in several malignancies and is hypothesized to
promote a migratory phenotype in hypoxic breast carcinomas. This study aims to …

Purpose: The objective of this study was to investigate the expression of cyclooxygenase (COX)-2
in human choroidal neovascular membranes. Methods: Paraffin-embedded sections …

Background Uveal melanoma (UM) cell lines, when exposed to blue light in vitro, show a
significant increase in proliferation. In order to determine if similar effects could be seen in vivo, …

Background Ocular melanoma is easily treated by the removal of the eye or through plaque
radiotherapy. However, after removal or control of the primary tumor, patients can develop …

The expression of cyclooxygenase-2 (COX-2) has been reported as an indicator of poor
prognosis in a wide variety of human tumors, including colon, breast and uveal melanoma (UM). …

Purpose: To examine the immunohistochemical profile of heat shock protein 90 (Hsp90) in
uveal melanoma and the cytotoxicity of an Hsp90 inhibitor, 17-allylamino-17-…

Background The aim of this study was to characterize the presence and roles of CXCL12,
CXCL8, CXCL1, and HGF in five human uveal melanoma cell lines, using different methods, in …

Biologic agents targeting oncogenes have encourage researchs trying to correlate the role
of tyrosine kinase in the pathogenesis of tumours. Osteosarcoma is a high grade aggressive …

Purpose Uveal melanoma (UM) is the most common intra-ocular tumor in adults. Despite
advances in diagnosis and treatment, the survival rate of UM has not increased in the last …